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Blood Transfusion
Red Blood Cell Transfusion for Cardiac Arrest
Phase 1
Waitlist Available
Led By Sam Parnia, MD
Research Sponsored by NYU Langone Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Adult patients, age ≥18 and <85 years
Experience prolonged, non-trauma-related in-hospital cardiac arrest, defined by cessation of heartbeat and respiration requiring CPR for at least 10 minutes
Must not have
Age <18 years old
Age > 85 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6-72 hours after rosc
Summary
"This trial aims to study the feasibility of giving packed red blood cells during cardiac arrest to improve oxygen delivery to the brain and other vital organs during CPR. They will also assess the effects of this transfusion
Who is the study for?
This trial is for individuals experiencing cardiac arrest. It aims to see if giving packed red blood cells (PRBC) during resuscitation can help deliver more oxygen to the brain and other organs.
What is being tested?
The study tests whether 1 or 2 units of PRBCs, compared with saline, improve outcomes like brain oxygen levels, chances of restarting the heart without assistance, survival rates, and neurological health after a cardiac arrest.
What are the potential side effects?
Potential side effects may include reactions to transfusion such as fever, allergic responses, lung injury from fluid overload or immune response. There's also a risk of infection transmission through blood.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 18 and 85 years old.
Select...
I had a heart stoppage in the hospital needing CPR for 10+ minutes.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I am under 18 years old.
Select...
I am over 85 years old.
Select...
I cannot start the study treatment within 20 minutes after a heart attack.
Select...
My heart started beating on its own within 10 minutes of CPR.
Select...
I am currently pregnant.
Select...
I was hospitalized due to a heart attack caused by an injury.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 6-72 hours after return of spontaneous circulation (rosc)
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6-72 hours after return of spontaneous circulation (rosc)
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
All-cause mortality
Frequency of antibody-mediated transfusion reactions
Frequency of non-immune reactions
+1 moreSecondary study objectives
CPC score
Trial Design
3Treatment groups
Experimental Treatment
Placebo Group
Group I: Packed Red Blood Cells (2 units)Experimental Treatment1 Intervention
1000 mL of packed red blood cells
Group II: Packed Red Blood Cells (1 unit)Experimental Treatment1 Intervention
500 mL of packed red blood cells
Group III: Saline solutionPlacebo Group1 Intervention
Treatment of 500 mL of normal saline.
Find a Location
Who is running the clinical trial?
NYU Langone HealthLead Sponsor
1,415 Previous Clinical Trials
856,173 Total Patients Enrolled
Sam Parnia, MDPrincipal InvestigatorNYU Langone Health