← Back to Search

Personalized Diet for Cardiometabolic Health

N/A

Recruiting

Led By Jaapna Dhillon, PhD

Research Sponsored by University of Missouri-Columbia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Non-smoker >1 year or more

Age: 18-35 years of age

Must not have

Coronary artery disease, peripheral artery disease, congestive heart failure, or dyslipidemia requiring drug therapy

Uncontrolled hypertension and blood pressure ≥ 180/110 Diabetes

Timeline

Screening 3 weeks

Treatment Varies

Follow Up every 4 weeks over the 8 week intervention

Awards & highlights

No Placebo-Only Group

Summary

This trial will study how a better diet impacts heart health and metabolism for black and white adults, as well as how the gut microbiome is affected.

Who is the study for?

This trial is for young Black and non-Hispanic White adults aged 18-35 with a BMI of 25-45. Participants should have stable weight, consistent diet and activity patterns, be non-smokers for at least a year, and willing to eat nuts, fruits, and vegetables. Those with allergies to these foods, gastrointestinal issues or surgery history, HIV positive status or recent drug use affecting metabolism are excluded.

What is being tested?

The study compares the effects of personalized dietary advice versus conventional dietary guidance on heart health outcomes and how they relate to gut bacteria in minority young adults. It aims to see if tailored diets can better improve body's sugar and fat processing compared to standard advice.

What are the potential side effects?

Since this trial involves dietary changes rather than medication or invasive procedures, side effects may include digestive discomfort as the body adjusts to new foods. However specific side effects will depend on individual reactions to the diet changes.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have not smoked for over a year.

Select...

I am between 18 and 35 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I am on medication for heart disease or high cholesterol.

Select...

My blood pressure is very high and I have diabetes.

Select...

I am HIV positive.

Select...

I have a gastrointestinal condition or have had bariatric surgery.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ every 4 weeks over the 8 week intervention

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~every 4 weeks over the 8 week intervention

This trial's timeline: 3 weeks for screening, Varies for treatment, and every 4 weeks over the 8 week intervention for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in blood pressure

Change in diet quality

Change in endothelial function

+7 more

Secondary study objectives

24-hour appetite ratings

Acceptance rating of foods

Anthropometrics

+4 more

Other study objectives

Attention score

Food environment perceptions

Memory

+1 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups

Experimental Treatment

Group I: Personalized diet - White adultsExperimental Treatment1 Intervention

Young White adults in this group will receive tailored nutrition counseling from a dietitian. To facilitate meeting their dietary goals, participants will be provided with nuts, fruits, and vegetables.

Group II: Personalized diet - Black adultsExperimental Treatment1 Intervention

Young Black adults in this group will receive tailored nutrition counseling from a dietitian. To facilitate meeting their dietary goals, participants will be provided with nuts, fruits, and vegetables.

Group III: Conventional dietary advice- White adultsExperimental Treatment1 Intervention

Young White adults will receive non-personalized, conventional dietary advice based on the MyPlate guidelines.

Group IV: Conventional dietary advice- Black adultsExperimental Treatment1 Intervention

Young Black adults will receive non-personalized, conventional dietary advice based on the MyPlate guidelines.

0 / 6Eligibility criteria met