← Back to Search

Apple vs Cranberry Juice for UTI Prevention in Healthy Women

N/A

Waitlist Available

Led By Liwei Gu, PhD

Research Sponsored by University of Florida

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Healthy women participants;

Healthy women participants

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline up to 21 days of each intervention

Awards & highlights

No Placebo-Only Group

Summary

This trial found that some women who drink cranberry juice are less likely to get UTIs, but they don't know why. It could be because of the way the body processes the juice, which varies from person to person.

Who is the study for?

This trial is for healthy women with a Body Mass Index (BMI) between 18.5 and 29.9, weighing at least 110 pounds. It's not suitable for those on medications that could affect the study results, pregnant or breastfeeding women, individuals with significant health issues, smokers, or frequent alcohol users.

What is being tested?

The study is examining how apple juice and cranberry juice might influence urinary tract infection (UTI) susceptibility in women by looking at their gut microbiome. The goal is to understand why cranberry juice has had mixed results in preventing UTIs.

What are the potential side effects?

Since the interventions involve common beverages like apple and cranberry juice, side effects are expected to be minimal but may include mild digestive discomfort or allergic reactions in rare cases.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am a healthy woman.

Select...

I am a healthy woman.

Select...

I weigh at least 110 pounds.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline up to 21 days of each intervention

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline up to 21 days of each intervention

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline up to 21 days of each intervention for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in the unrinary anti-adhesion activity of UTI susceptible women

Secondary study objectives

Determine the compositional differences of gut microbiome in responders and non-responders after the cranberry juice intake

Identify anti-adhesion urinary biomarkers in responders versus non-responders after the cranberry juice intake

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Cranberry juice consumptionExperimental Treatment1 Intervention

Participants deemed as responders and non-responders will be given 20-30 oz (590-885 mL) of cranberry juice daily for 3 weeks.

Group II: Apple juice consumptionExperimental Treatment1 Intervention

Participants deemed as responders and non-responders will be given 20-30 oz (590-885 mL) apple juice with matching sugar and calories daily for 3 weeks.

0 / 3Eligibility criteria met