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Neurotoxin

Botulinum toxin injections for Chronic Exertional Compartment Syndrome (Botox Trial)

Phase 2 & 3
Waitlist Available
Led By Brett Boyce, MD
Research Sponsored by 375th Medical Group, Scott Air Force Base
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights
No Placebo-Only Group

Summary

We will investigate the feasibility of a simple outpatient one time injection regimen for the treatment of Chronic Exertional Compartment Syndrome (CECS). We think botulinum toxin injections will be a potentially cost-effective, low-risk alternative to surgery in reducing pain and returning patients to full activity.

Eligible Conditions
  • Chronic Exertional Compartment Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Lower Extremity Functional Index

Side effects data

From 2018 Phase 3 trial • 351 Patients • NCT02002884
6%
Nasopharyngitis
2%
Bronchitis
1%
Epilepsy
100%
80%
60%
40%
20%
0%
Study treatment Arm
MP Low Dose Group
MP Mid Dose Group
MP High Dose Group
OLEX (3 Injections)

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Botulinum toxin injectionsExperimental Treatment1 Intervention
Botulinum toxin injections for chronic compartment syndrome
Group II: surgical fasciotomyActive Control1 Intervention
surgical fasciotomy for chronic compartment syndrome

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Who is running the clinical trial?

375th Medical Group, Scott Air Force BaseLead Sponsor
1 Previous Clinical Trials
75 Total Patients Enrolled
Brett Boyce, MDPrincipal InvestigatorPrincipal Investigator
~0 spots leftby Oct 2025
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