← Back to Search

Alkylating agents

MB-102 for Blastic Plasmacytoid Dendritic Cell Neoplasm

Phase 1 & 2
Waitlist Available
Led By Lihua E Budde, MD
Research Sponsored by Mustang Bio
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 3 years
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing a new treatment called MB-102 for patients with BPDCN, a type of cancer that has come back or did not respond to other treatments. The study will determine the safest dose and evaluate the effectiveness of MB-102 for these patients.

Eligible Conditions
  • Blastic Plasmacytoid Dendritic Cell Neoplasm

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 3 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 3 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Phase 1: Maximum Tolerated Dose (MTD) and recommended Phase 2 dose
Phase 1: Safety and Tolerability as measured by the number of patients with treatment related adverse events
Phase 2: Response Rate of patients with BPDCN
Secondary study objectives
Phase 2 - Adverse events
Phase 2 - Change from Baseline in the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) Version 4.0.
Phase 2 - Number of patients showing evidence of replication competent lentivirus
+5 more

Side effects data

From 2023 Phase 3 trial • 249 Patients • NCT05425719
2%
Headache
100%
80%
60%
40%
20%
0%
Study treatment Arm
eGFR ≥ 70 mL/Min/1.73 m^2
eGFR < 70 mL/Min/1.73 m^2

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Relapsed or Refractory BPDCNExperimental Treatment3 Interventions
Treatment with MB-102.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cyclophosphamide
2010
Completed Phase 4
~2310
Fludarabine
2012
Completed Phase 4
~1860
MB-102
2019
Completed Phase 3
~280

Find a Location

Who is running the clinical trial?

Mustang BioLead Sponsor
3 Previous Clinical Trials
76 Total Patients Enrolled
Lihua E Budde, MDPrincipal InvestigatorCity of Hope Medical Center
~1 spots leftby Nov 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top