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Local Anesthetic

Buffered vs Non-Buffered Articaine for Pain

Phase 2
Recruiting
Led By Waleed Elmallah, PhD
Research Sponsored by Cleveland Dental Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Need a dental treatment in the upper anterior region
Males and females, age 18 to 60 years
Must not have
Periodontally affected teeth
Timeline
Screening 3 weeks
Treatment Varies
Follow Up immediate
Awards & highlights

Summary

This trial compares the pain experienced after getting a numbing injection with buffered articaine versus non-buffered articaine.

Who is the study for?
This clinical trial is open to individuals who are experiencing pain and require local anesthesia. Specific eligibility criteria for participation have not been provided, which suggests that the study may be broadly inclusive.
What is being tested?
The trial is investigating the difference in post-injection pain between two types of local anesthetics: buffered articaine and non-buffered articaine. Participants will receive one of these treatments to compare their effects on pain levels.
What are the potential side effects?
While specific side effects are not listed, common side effects from dental anesthetics like articaine can include temporary numbness, tingling sensations, or minor bruising at the injection site.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I need dental work on my front upper teeth.
Select...
I am between 18 and 60 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have gum disease affecting my teeth.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~immediate
This trial's timeline: 3 weeks for screening, Varies for treatment, and immediate for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Numerical Rate Scale (NRS)

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Buffered articaineExperimental Treatment1 Intervention
Group II: non buffered articaineActive Control1 Intervention

Find a Location

Who is running the clinical trial?

Cleveland Dental InstituteLead Sponsor
5 Previous Clinical Trials
334 Total Patients Enrolled
2 Trials studying Pain
184 Patients Enrolled for Pain
Ahmed H Khalifa, PhDStudy ChairCleveland Dental Institute
Waleed Elmallah, PhDPrincipal InvestigatorCleveland Dental Institute
1 Previous Clinical Trials
80 Total Patients Enrolled
~12 spots leftby Oct 2024
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