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Exercise for Physical Activity Benefits (MoTrMito Trial)

N/A

Recruiting

Led By Owen T Carmichael, PhD

Research Sponsored by Pennington Biomedical Research Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Young Participants: Must be able to read and speak English well enough to provide informed consent and understand instructions

Old Age Participants: Aged >=60 y

Must not have

All benzodiazepines

Clinical diagnosis of Chronic Obstructive Pulmonary Disease (COPD)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up after week 12 visit - after all muscle biopsies and exercise training.

Awards & highlights

Summary

This trial is testing whether aerobic or resistance exercise can improve the mitochondria in skeletal muscle cells, which could lead to better metabolic health and function.

Who is the study for?

Healthy adults aged 18-39, 40-59, and over 60 with a BMI between >19 to <35 kg/m2 who can consent and understand English. Excluded are those on certain medications, planning weight changes, with chronic diseases like diabetes or heart conditions, high blood pressure or abnormal blood tests, recent substance abuse including tobacco and excessive alcohol intake.

What is being tested?

The study examines if aerobic or resistance exercise improves mitochondrial capacity in muscle cells across different age groups. It aims to see if these exercises affect metabolic health and functional capacity by changing how genes respond to exercise.

What are the potential side effects?

Since the trial involves physical exercises like isometric contractions, potential side effects may include muscle soreness, fatigue, joint pain or discomfort during or after exercising. However no invasive medical interventions are involved.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I can read and speak English well enough to understand medical instructions.

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I am 60 years old or older.

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My BMI is between 19 and 35.

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I can read and speak English well enough to understand study instructions.

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I am between 18 and 39 years old.

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My BMI is between 19 and 35.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am not taking any benzodiazepines.

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I have been diagnosed with COPD.

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I am taking finasteride or dutasteride.

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I have abnormal bleeding or a blood clotting disorder.

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I have a history of bleeding or clotting issues.

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I am not taking any medication specifically for weight loss.

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I am not taking any heart rhythm medications like amiodarone or quinidine.

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I have had a bone break from falling while standing or from a lower height.

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I am willing to stop my cholesterol medication for the study and can be re-checked after 3 months.

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I have not taken hormone therapy for cancer in the last 6 months.

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I am on long-term antibiotics or antivirals for an infection.

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I have long-term kidney problems.

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I am currently taking muscle relaxants.

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I am not currently using testosterone, DHEA, or anabolic steroids.

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I have not used drugs to increase muscle size or enhance workout results.

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I am currently using narcotics or drugs that act like them.

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I am currently taking medication for a psychiatric condition.

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I am taking medication to lower my cholesterol.

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I am not taking any antiplatelet drugs except for aspirin at or above 100 mg/day.

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I have diabetes.

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I don't use medium or long-acting sleep or calming drugs regularly.

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I am taking medication for osteoporosis that isn't calcium, vitamin D, or estrogen.

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I have taken short courses of oral steroids more than once in the past year.

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I regularly take NSAIDs or acetaminophen at least 3 days a week.

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I do not have an overactive thyroid or take medication to control my thyroid hormone levels.

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I use the substance or medication at least 3 days a week.

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I am 60 or older with a blood pressure of 150/90 or higher.

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I have a serious heart condition or have had a stroke.

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I am currently taking medication for ADHD.

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I use tobacco or e-cigarette products at least 3 days a week.

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I am not currently taking any medications that would exclude me from the trial.

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I am HIV positive.

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I take medication daily for ED.

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I am not currently taking any hormone-based cancer treatments.

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I am taking two or more medications for depression.

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I haven't changed the dose of any of my medications in the last 3 months.

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I am taking medication to stabilize my mood.

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I take 75 mg or more of tricyclic antidepressants daily.

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I am under 60 and my blood pressure is high.

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I am taking metformin.

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I am on long-term oral steroids.

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I use low-potency skin creams on more than 10% of my body.

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I am currently taking estrogen or progestin medications.

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My kidney function is reduced, with an eGFR below 60 mL/min.

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I am taking blood thinners.

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I have not donated platelets or plasma in the last week and do not plan to during the trial.

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I am taking medication for epilepsy.

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I am taking medication for diabetes.

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I have used lidocaine or another local anesthetic.

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I haven't taken any new medications in the last 3 months.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline visit - before any muscle biopsies or exercise training.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline visit - before any muscle biopsies or exercise training.

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline visit - before any muscle biopsies or exercise training. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Post-training 31P MRS measurement - Phosphocreatine recovery rate

Pre-training 31P MRS measurement - Phosphocreatine recovery rate

Trial Design

3Treatment groups

Active Control

Group I: Young Adults (Age group 18-39)Active Control1 Intervention

31P-Magnetic Resonance Spectroscopy exam on one thigh to measure mitochondrial capacity non-invasively after exercise training.

Group II: Middle Aged Adults (Age group 40-59)Active Control1 Intervention

31P-Magnetic Resonance Spectroscopy exam on one thigh to measure mitochondrial capacity non-invasively after exercise training.

Group III: Old Adults (Age group >60)Active Control1 Intervention

31P-Magnetic Resonance Spectroscopy exam on one thigh to measure mitochondrial capacity non-invasively after exercise training.

0 / 56Eligibility criteria met

Find a Location

Who is running the clinical trial?

AdventHealth Translational Research InstituteOTHER

48 Previous Clinical Trials

5,208 Total Patients Enrolled

Stanford UniversityOTHER

2,448 Previous Clinical Trials

17,491,974 Total Patients Enrolled

Wake Forest University Health SciencesOTHER

1,266 Previous Clinical Trials

1,013,287 Total Patients Enrolled

Media Library

Isometric Contraction Exercise Clinical Trial Eligibility Overview. Trial Name: NCT04799171 — N/A

Physical Activity Research Study Groups: Young Adults (Age group 18-39), Middle Aged Adults (Age group 40-59), Old Adults (Age group >60)

Physical Activity Clinical Trial 2023: Isometric Contraction Exercise Highlights & Side Effects. Trial Name: NCT04799171 — N/A

Isometric Contraction Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT04799171 — N/A

~103 spots leftby Sep 2025

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