Your session is about to expire
What is Paroxetine Hydrochloride
ParoxetineThe Generic name of this drug
Treatment SummaryParoxetine, also known as Paxil, is a drug used to treat a range of mental health issues including anxiety, depression, PTSD, and menopause symptoms. It was introduced in the 1990s and is more powerful than other SSRIs (selective serotonin reuptake inhibitors), meaning it is more likely to cause withdrawal effects if stopped suddenly. Paroxetine is generally considered safe for most patients, with a similar list of side effects to other SSRIs, although a controlled-release version was developed to help reduce the risk of nausea.
Paxilis the brand name
Paroxetine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Paxil
Paroxetine
1993
429
Approved as Treatment by the FDA
Paroxetine, also known as Paxil, is approved by the FDA for 3 uses which include Vasomotor Symptoms Associated With Menopause and Hot flashes .Vasomotor Symptoms Associated With Menopause
Helps manage Vasomotor Symptoms Associated With Menopause
Hot flashes
Helps manage Menopause
Hot Flashes
Helps manage Vasomotor Symptoms Associated With Menopause
Effectiveness
How Paroxetine Hydrochloride Affects PatientsParoxetine is used to treat depression, anxiety disorders, post-traumatic stress disorder, obsessive-compulsive disorder, and the hot flashes associated with menopause. It works by blocking the reuptake of serotonin, a neurotransmitter in the brain. The effects of paroxetine usually become noticeable after about 6 weeks. However, if taken with certain medications that block monoamine oxidase (MAO), it can cause serotonin syndrome, a potentially dangerous side effect. Therefore, it is recommended to wait two weeks before taking paroxetine after stopping MAO inhibitors.
How Paroxetine Hydrochloride works in the bodyParoxetine is a medication that works by increasing the amount of serotonin in the brain. This helps to reduce symptoms associated with depression, anxiety, and menopause. It does this by blocking the reuptake of serotonin, meaning it prevents serotonin from leaving the brain. Paroxetine also has a small effect on other brain chemicals, but it mainly works on serotonin. This drug takes some time for its effects to be seen, as it first needs to activate certain receptors, which then allows serotonin to build up in the brain.
When to interrupt dosage
The measure of Paroxetine Hydrochloride is subject to the diagnosed affliction, including Post Traumatic Stress Disorder, Depression and Irritable Bowel Syndrome (IBS). The dosage can differ as per the technique of delivery (e.g. Oral or Capsule - Oral) featured in the table below.Condition
Dosage
Administration
Generalized Anxiety Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Irritable Bowel Syndrome
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Depression
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Hot Flashes
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Premature Ejaculation
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Panic Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Social Anxiety Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Obsessive-Compulsive Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Hot flashes
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Post Traumatic Stress Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Warnings
Paroxetine Hydrochloride has five contraindications, therefore it should not be administered in circumstances of the conditions detailed in the following table.Paroxetine Hydrochloride ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Serotonin Syndrome
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Paroxetine may interact with Pulse Frequency
Common Paroxetine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Paroxetine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Paroxetine.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Paroxetine.
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Paroxetine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Paroxetine is combined with Aclidinium.
Paroxetine Hydrochloride Toxicity & Overdose RiskThe toxic dose of paroxetine in mice and rats is 350mg/kg. A fatal overdose of paroxetine is typically around 400mg, while the highest reported non-fatal overdose was 2000mg. Symptoms of a paroxetine overdose include fatigue, fever, difficulty sleeping, high blood pressure, rapid heartbeat, nausea, vomiting, drowsiness, shaking, dizziness, irritability, anxiety, headache, excessive sweating, enlarged pupils, seizures, and changes in mental status. There is no known antidote for an overdose of paroxetine.
Paroxetine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Paroxetine Hydrochloride?
Currently, 539 active trials are being conducted to investigate the utility of Paroxetine Hydrochloride in treating Post Traumatic Stress Disorder, Premature Ejaculation and Menopausal symptoms.Condition
Clinical Trials
Trial Phases
Generalized Anxiety Disorder
2 Actively Recruiting
Not Applicable
Depression
198 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Social Anxiety Disorder
18 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Obsessive-Compulsive Disorder
17 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 1
Post Traumatic Stress Disorder
238 Actively Recruiting
Early Phase 1, Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1
Panic Disorder
9 Actively Recruiting
Not Applicable, Phase 2
Irritable Bowel Syndrome
8 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Early Phase 1
Hot Flashes
0 Actively Recruiting
Premature Ejaculation
0 Actively Recruiting
Hot flashes
15 Actively Recruiting
Phase 1, Not Applicable, Early Phase 1, Phase 2, Phase 4
Paroxetine Hydrochloride Reviews: What are patients saying about Paroxetine Hydrochloride?
5Patient Review
3/10/2019 Hot flashes have decreased significantly, now only occurring a few times per day. I've also been feeling sleepy in the evenings, but it's a welcome opportunity to relax. Another plus is that I've lost weight due to lack of appetite. Finally, I have more energy in the mornings and can be more productive with my time.
5Patient Review
7/2/2022 I've been taking paroxetine for 25 years and it's really improved my quality of life. I've tried to wean myself off a few times but the anxiety and depression come back too strong without it. I'm currently on a maintenance dose of 20mg and doing well.
5Patient Review
12/15/2018 This is the best medication I've tried for hot flashes.
5Patient Review
7/2/2022 I've been taking Paroxetine for 25 years and it has completely changed my life. I've tried to wean myself off a few times, but the anxiety and depression come back extremely quickly and severely without it. I'm stable on a maintenance dose of 20mg now, and at 61 years old, I'm in excellent mental and physical health.
5Patient Review
9/10/2017 I've been using this treatment for a few years and it works great for me.
Patient Q&A Section about paroxetine hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of taking paroxetine?
"headache, dizziness, weakness, difficulty concentrating, nervousness, forgetfulness, confusion, sleepiness."
Answered by AI
Is paroxetine a sleeping pill?
"This medication is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, and premenstrual dysphoric disorder.
Paroxetine is a drug that is used to treat various mental disorders. It is known as a selective serotonin reuptake inhibitor, which means that it helps to restore the balance of serotonin in the brain. This can improve symptoms such as mood swings, anxiety, and depression. It can also help to improve sleep, appetite, and energy levels, and restore interest in everyday activities."
Answered by AI
What is paroxetine hydrochloride used for?
"The drug Paroxetine is used to to treat a number of mental disorders which include: depression, OCD, panic disorder, generalized anxiety disorder, social anxiety disorder, premenstrual dysphoric disorder, and posttraumatic stress disorder."
Answered by AI
Is paroxetine a strong antidepressant?
"Among the SSRIs, fluoxetine and paroxetine are highly potent inhibitors of 2D6, while sertraline is only a moderate inhibitor. Women taking SSRIs that weakly inhibit 2D6 have a 8.8% risk of breast cancer recurrence, as opposed to the 7.5% risk in women not taking these drugs."
Answered by AI