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Vitamin B3 Analog

Nicotinamide for Skin Cancer Prevention (SPRINTR-Pilot Trial)

Phase 2
Waitlist Available
Led By An-Wen Chan, MD DPhil
Research Sponsored by Women's College Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year

Summary

This trial will test if a drug called nicotinamide can help prevent skin cancer in people who have had organ transplants. If it is successful, it will become a larger trial.

Eligible Conditions
  • Head and Neck Cancers
  • Basal Cell Carcinoma
  • Skin Cancer
  • Squamous Cell Carcinoma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Drug interactions
Feasibility (pertaining to adherence to follow-up assessments)
Feasibility (pertaining to adherence to intervention)
+5 more
Secondary study objectives
Baseline prevalence of cognitive impairment (substudy)
Feasibility of recruiting for neurocognitive substudy
Pooled standard deviation of Animal Naming Task scores (substudy)
+5 more

Side effects data

From 2022 Phase 2 trial • 46 Patients • NCT03061474
25%
Diarrhoea
17%
Urinary tract infection
17%
Fall
8%
Constipation
8%
Vomiting
8%
Anxiety
8%
Laboratory test abnormal
8%
Back pain
4%
Cognitive disorder
4%
Upper respiratory tract infection
4%
Coccydynia
4%
Agitation
4%
Fungal infection
4%
Dizziness
4%
Dysgeusia
4%
Syncoper
4%
Vitamin D deficiency
4%
Glomerular Ffiltration rate decreased
4%
Hypokalaemia
4%
Basal cell carcinoma
4%
Pneumonia
4%
Tremor
4%
Blood testosterone decreased
4%
Weight decreased
4%
Hyperlipidaemia
4%
Foot deformity
4%
Osteoporosis
4%
Headache
4%
Eructation
4%
Pleocytosis
4%
Limb injury
4%
Renal cyst
4%
Laceration
4%
Myalgia
4%
Diabetes mellitus
4%
Arthralgia
4%
Thrombocytopenia
4%
Dyspepsia
4%
Infection
4%
Post lumbar puncture syndrome
4%
Neuropathy peripheral
4%
Colorectal cancer
4%
Tooth abscess
4%
Colitis ulcerative
4%
Hiatus hernia
4%
Dehydration
4%
Parkinson's disease
4%
Transaminases increased
4%
Viral upper respiratory tract infection
4%
Foot fracture
4%
Head Injury
4%
Actinic keratosis
4%
Miliaria
4%
Penile ulceration
4%
Psoriasis
4%
Rash
4%
Urticaria
4%
Cancer surgery
100%
80%
60%
40%
20%
0%
Study treatment Arm
Nicotinamide
Placebo

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: NicotinamideExperimental Treatment1 Intervention
Group II: PlaceboPlacebo Group1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Nicotinamide
2021
Completed Phase 3
~2810

Find a Location

Who is running the clinical trial?

NOW FoodsOTHER
5 Previous Clinical Trials
571 Total Patients Enrolled
The Kidney Foundation of CanadaOTHER
15 Previous Clinical Trials
3,193 Total Patients Enrolled
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,388 Previous Clinical Trials
26,517,953 Total Patients Enrolled

Media Library

Nicotinamide (Vitamin B3 Analog) Clinical Trial Eligibility Overview. Trial Name: NCT03769285 — Phase 2
Head and Neck Cancers Research Study Groups: Nicotinamide, Placebo
Head and Neck Cancers Clinical Trial 2023: Nicotinamide Highlights & Side Effects. Trial Name: NCT03769285 — Phase 2
Nicotinamide (Vitamin B3 Analog) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03769285 — Phase 2
~17 spots leftby Nov 2025
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