~1 spots leftby Apr 2026

Evaluation of Endometriosis With 18F-fluoroestradiol PET / MRI

Recruiting in Palo Alto (17 mi)
JO
Overseen byJorge Oldan, MD
Age: 18+
Sex: Female
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 2
Waitlist Available
Sponsor: University of North Carolina, Chapel Hill
No Placebo Group
Prior Safety Data

Trial Summary

What is the purpose of this trial?

Purpose: The primary objective is to evaluate the sensitivity and specificity of 18F-fluoroestradiol (FES) PET/MRI for evaluating endometriosis. Participants: A total of 12 participants will be recruited from individuals with clinically suspected endometriosis who are scheduled for planned operative laparoscopy at the University of North Carolina at Chapel Hill (UNC). Procedures (methods): This is a prospective, one arm, single center study of 12 subjects with clinically suspected endometriosis to demonstrate FES PET/MR's clinical utility for diagnosis of endometriosis. This study will be an evaluation of the radiotracer, FES, which binds to estrogen receptors and has previously been used to study estrogen receptor expression in tumors, to detect endometriosis. Participants will undergo one FES PET/MR scan within 4 weeks prior to their scheduled surgery. Participants will also complete questionnaires regarding their condition, pain, and quality of life.

Research Team

JO

Jorge Oldan, MD

Principal Investigator

University of North Carolina, Chapel Hill

Eligibility Criteria

Inclusion Criteria

Age 18 or older
Female of childbearing age
Clinically suspected (symptomatic) endometriosis.
See 2 more

Treatment Details

Interventions

  • 18F-fluoroestradiol (Radiopharmaceutical)
Participant Groups
1Treatment groups
Experimental Treatment
Group I: 18F-fluoroestradiol PET / MRIExperimental Treatment1 Intervention
All enrolled subjects will receive the tracer and then have a PET/MRI scan.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of North Carolina, Chapel Hill

Lead Sponsor

Trials
1,588
Recruited
4,364,000+
Dr. Peggy P. McNaull profile image

Dr. Peggy P. McNaull

University of North Carolina, Chapel Hill

Chief Medical Officer

MD from Louisiana State University School of Medicine

Dr. Lynne Fiscus profile image

Dr. Lynne Fiscus

University of North Carolina, Chapel Hill

Chief Executive Officer since 2020

MD from Georgetown University, MPH from UNC

North Carolina Translational and Clinical Sciences Institute

Collaborator

Trials
61
Recruited
4,600+

Dr. Nicholas Shaheen

North Carolina Translational and Clinical Sciences Institute

Chief Executive Officer

MD, MPH

Dr. John Buse

North Carolina Translational and Clinical Sciences Institute

Chief Medical Officer since 2020

MD, PhD