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Xanthine Oxidase Inhibitor

Arhalofenate 400 mg for Gout

Phase 2
Waitlist Available
Research Sponsored by CymaBay Therapeutics, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up percent change from baseline in serum uric acid at week 4
Awards & highlights

Summary

The purpose of this study is to evaluate the efficacy, safety and tolerability of MBX-102 in combination with allopurinol compared to allopurinol alone when administered orally once a day for four weeks to gout patients with an inadequate hypouricemic response to allopurinol alone.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~percent change from baseline in serum uric acid at week 4
This trial's timeline: 3 weeks for screening, Varies for treatment, and percent change from baseline in serum uric acid at week 4 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Serum Uric Acid

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Arhalofenate 600 mgExperimental Treatment3 Interventions
Arhalofenate 600 mg plus allopurinol 300 mg
Group II: Arhalofenate 400 mgExperimental Treatment3 Interventions
Arhalofenate 400 mg plus allopurinol 300 mg
Group III: AllopurinolActive Control3 Interventions
Placebo plus Allopurinol 300 mg
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Allopurinol
FDA approved
Arhalofenate
Not yet FDA approved
Colchicine
FDA approved

Find a Location

Who is running the clinical trial?

CymaBay Therapeutics, Inc.Lead Sponsor
22 Previous Clinical Trials
3,156 Total Patients Enrolled
4 Trials studying Gout
374 Patients Enrolled for Gout
~7 spots leftby Sep 2025
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