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Vasodilator

Isosorbide Mononitrate for Heart Failure (NEAT-HFpeF Trial)

Phase 2
Waitlist Available
Led By Kevin Anstrom, PhD
Research Sponsored by Adrian Hernandez
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 11-12 weeks
Awards & highlights
All Individual Drugs Already Approved

Summary

A randomized, double-blinded, placebo-controlled crossover study to assess effect of isosorbide mononitrate with dose up-titration on activity tolerance as assessed by (hip-worn, tri-axial) accelerometry.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~11-12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 11-12 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Arbitrary Accelerometry Units (AAU) (Phase I)
Arbitrary Accelerometry Units (AAU) (Phase II)
Secondary study objectives
Borg Score During 6 Minute Walk Test (Phase I)
Borg Score During 6 Minute Walk Test (Phase II)
Improvement in Daily Activity - Area Under the Curve (Phase I)
+12 more

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Isosorbide MononitrateActive Control1 Intervention
Isosorbide Mononitrate with dose up-titration (30 to 120 mg/day over 4 weeks)
Group II: Isosorbide Mononitate PlaceboPlacebo Group1 Intervention
Isosorbide Mononitrate placebo with dose up-titration (30 to 120 mg/day over 4 weeks)

Find a Location

Who is running the clinical trial?

Mayo ClinicOTHER
3,318 Previous Clinical Trials
2,950,922 Total Patients Enrolled
75 Trials studying Heart Failure
26,089 Patients Enrolled for Heart Failure
Adrian HernandezLead Sponsor
6 Previous Clinical Trials
1,746 Total Patients Enrolled
5 Trials studying Heart Failure
386 Patients Enrolled for Heart Failure
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,914 Previous Clinical Trials
47,758,029 Total Patients Enrolled
209 Trials studying Heart Failure
677,629 Patients Enrolled for Heart Failure
~10 spots leftby Oct 2025
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