~49 spots leftby Apr 2026

A Study of VB-111 With Paclitaxel vs Paclitaxel for Treatment of Recurrent Platinum-Resistant Ovarian Cancer (OVAL)

(OVAL Trial)

Recruiting in Palo Alto (17 mi)
+93 other locations
Age: 18+
Sex: Female
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 3
Waitlist Available
Sponsor: Vascular Biogenics Ltd. operating as VBL Therapeutics
No Placebo Group
Pivotal Trial (Near Approval)
Prior Safety Data

Trial Summary

What is the purpose of this trial?

The purpose of this phase 3, randomized, multicenter study is to compare VB-111 and paclitaxel to placebo and paclitaxel in adult patients with Recurrent Platinum-Resistant Ovarian Cancer.

Research Team

Eligibility Criteria

Inclusion Criteria

Histologically confirmed epithelial ovarian cancer and documented disease.
Patients must have platinum-resistant disease
ECOG PS 0-1.
See 6 more

Treatment Details

Interventions

  • Paclitaxel (Anti-microtubule agent)
  • VB-111 (Virus Therapy)
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Arm 1Experimental Treatment1 Intervention
VB-111 + Paclitaxel
Group II: Arm 2Active Control1 Intervention
Placebo + Paclitaxel

Paclitaxel is already approved in Canada for the following indications:

🇨🇦
Approved in Canada as Paclitaxel for:
  • Ovarian cancer
  • Breast cancer
  • Non-small cell lung cancer
  • Kaposi's sarcoma

Find a Clinic Near You

Who Is Running the Clinical Trial?

Vascular Biogenics Ltd. operating as VBL Therapeutics

Lead Sponsor

Trials
12
Recruited
1,700+

GOG Foundation

Collaborator

Trials
48
Recruited
18,500+