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Vitamin

Evaluation of Nicotinamide Riboside in Prevention of Small Fiber Axon Degeneration and Promotion of Nerve Regeneration

Phase 2
Waitlist Available
Led By Ahmet Hoke
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months

Summary

This trial will test if a nutritional supplement called nicotinamide riboside can prevent and repair nerve damage caused by applying capsaicin to the skin in healthy people. The study aims to see if this supplement can help nerves stay healthy and grow back after damage.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Denervation of Skin
Reinnervation of Skin

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Nicotinamide RibosideExperimental Treatment1 Intervention
Experimental group of participants will receive Nicotinamide riboside at a dose of 900 mg twice a day orally.
Group II: PlaceboPlacebo Group1 Intervention
Study participants in the placebo arm will receive placebo pills that are similar in size and shape to the experimental group drug.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Nicotinamide riboside
2021
Completed Phase 3
~390

Find a Location

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor
2,332 Previous Clinical Trials
14,874,855 Total Patients Enrolled
2 Trials studying Small Fiber Neuropathy
11 Patients Enrolled for Small Fiber Neuropathy
Adelson Medical Research FoundationUNKNOWN
Ahmet HokePrincipal InvestigatorJohns Hopkins University
~9 spots leftby Dec 2025