Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension
(ACE Trial)

Recruiting in Palo Alto (17 mi)

Overseen byMichal Fishel Bartal, MD

Age: 18+

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Waitlist Available

Sponsor: The University of Texas Health Science Center, Houston

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?

This trial is testing a combined pill of two medications to help lower blood pressure in women who have high blood pressure after giving birth. The pill works by relaxing blood vessels and removing extra salt and water from the body. The goal is to see if this combined pill is more effective than the usual treatment.

Research Team

Michal Fishel Bartal, MD

Principal Investigator

UT Health Science Center

Eligibility Criteria

Inclusion Criteria

Chronic hypertension requiring blood pressure medication postpartum

Postpartum women at ≥ 18 years of age

Postpartum diagnosis of persistent hypertension (2 measurements of Systolic BP ≥150 and/or diastolic BP ≥ 100 or systolic BP ≥140 and/or diastolic BP ≥ 90 for people with diabetes) requiring an oral medication based on the ACOG criteria or

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Exclusion Criteria

Hyperkalemia (serum potassium >5 mEq/L) during current admission

Pulmonary edema

Urine output < 30 cc/h prior to screening for eligibility

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