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Multidomain Exercise & Cognitive Training for Aging-related Cognitive Decline (ACTIONcR Trial)

N/A

Recruiting

Led By Louis Bherer, PhD

Research Sponsored by Louis Bherer

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Normal or corrected vision and normal hearing for their age range

Adult aged 60 and older

Must not have

Severe exercise intolerance

Symptomatic aortic stenosis

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline and post-intervention at 12 months.

Awards & highlights

No Placebo-Only Group

Summary

This trial is designed to investigate the effect of different types of exercise on the neurocognitive functioning of sedentary older adults with and without cardiovascular risk factors.

Who is the study for?

This trial is for sedentary adults aged 60 and older who are generally healthy, with no cognitive impairment (scoring at least 25 on the MMSE), and have normal vision and hearing for their age. It's not suitable for those with severe cardiovascular or respiratory diseases, excessive alcohol consumption, certain heart conditions, uncontrolled mental health issues within the past six months, neurological diseases or dementia.

What is being tested?

The ACTIONcardioRisk trial examines if a combination of aerobic exercises, resistance training, and brain exercises can help prevent memory loss in older adults who don't exercise much but may have heart health risks. Participants will be guided through specific physical and cognitive activities.

What are the potential side effects?

While this program focuses on safe exercises and brain games designed to improve health without significant risk, some participants might experience muscle soreness or fatigue due to new physical activities. Cognitive training typically does not cause side effects.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My vision and hearing are normal or corrected to normal for my age.

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I am 60 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I cannot tolerate heavy physical activity.

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I have symptoms from a narrowed heart valve.

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I have long-term heart failure.

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I have atrial fibrillation.

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I have a neurological condition.

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I have a respiratory condition like asthma or COPD.

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I have been diagnosed with atherosclerosis in my brain, limbs, or heart.

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I have dangerous heart rhythms when I exercise.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline and post-intervention at 12 months.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline and post-intervention at 12 months.

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and post-intervention at 12 months. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in episodic memory

Change in executive functions

Change in general cognitive functioning

+1 more

Secondary study objectives

Change in brain structure

Change in cerebral activity

Change in cerebral autoregulation - frontal cortical region

+6 more

Other study objectives

Baseline level of physical activity

Change in Balance performance

Change in Dietary patterns

+35 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: Physical exercise interventionExperimental Treatment1 Intervention

The physical exercises intervention will include aerobic and resistance exercises training, three sessions per week for 46 weeks. Participants will be allowed to perform cognitive and exercise training sessions either home-based or centre-based.

Group II: Multidomain interventionExperimental Treatment2 Interventions

The multidomain intervention will combine a cognitive training with aerobic and resistance exercises training, three sessions per week for 46 weeks. Participants will be allowed to perform cognitive and exercise training sessions either home-based or centre-based.

Group III: Active control interventionActive Control1 Intervention

The active control intervention will include stretching and toning exercises, three sessions per week for 46 weeks. Participants will be allowed to perform cognitive and exercise training sessions either home-based or centre-based.

0 / 10Eligibility criteria met