EVLP for Lung Transplant
(EVLP-CHUM Trial)

Recruiting in Palo Alto (17 mi)

Overseen byPasquale Ferraro, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

No Placebo Group

Trial Summary

What is the purpose of this trial?The overall objective of this study is to evaluate the clinical effectiveness of the novel technique of donor EVLP in increasing lung transplant activity by allowing previously unusable donor lungs to be safely used in clinical lung transplantation. Furthermore, to utilize the EVLP technique in research settings thus allowing the evaluation of inflammatory molecules (biomarkers) that would benefit a successful pre-conditioning and increase knowledge of the lungs inflammatory response before transplantation.

Eligibility Criteria

This trial is for adults over 18 who are on the active waiting list for their first lung transplant and have given informed consent. They must re-confirm consent on the day of transplant and have received patient information sheets beforehand. It's not open to those under 18, without informed consent, or needing mechanical ventilation or ECMO support.

Inclusion Criteria

Patients already on or added to the active waiting list for first lung transplant

I will re-confirm my consent for the study on the day of my lung transplant.

I am 18 years old or older.

+1 more

Exclusion Criteria

I need a machine to help me breathe.

Patients not in possession of patient information sheets for the study prior to the day of lung transplant

I am under 18 years old.

+2 more

Participant Groups

The study tests a new technique called Ex Vivo Lung Perfusion (EVLP) which aims to make previously unusable donor lungs safe for transplantation. The process also allows researchers to study inflammatory responses in the lungs before they're transplanted.

2Treatment groups

Experimental Treatment

Active Control

Group I: EVLP GroupExperimental Treatment1 Intervention

Recipients receive reconditioned EVLP donor lungs and current standard of care for lung transplant is administered.

Group II: Standard GroupActive Control1 Intervention

Recipients receive standard donor lungs as per current clinical practice. No experimental procedures will be carried out.