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Morphine for Abdominal Pain/Gastrointestinal Issues

N/A
Waitlist Available
Led By Mercedes M Uribe, MD
Research Sponsored by University of Texas Southwestern Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Approved for 5 Other Conditions
All Individual Drugs Already Approved

Summary

Surgeons are the individuals who will operate on a patient if it is determined to be necessary after they present with abdominal pain. For that reason, the investigators want to study if giving a medicine (morphine) to children presenting to the ED with abdominal pain will alleviate pain without changing the patient's physical exam and the subsequent surgeon's decision. The investigators also will record any side effects of morphine, any associated surgical complications, and to identify the ultimate diagnosis.

Eligible Conditions
  • Abdominal Pain/Gastrointestinal Issues
  • Abdominal Pain

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Side effects data

From 2012 Phase 4 trial • 50 Patients • NCT01322360
36%
Nausea
34%
Constipation
22%
Oxygen Saturation Decreased
18%
Tachypnoea
16%
Pyrexia
14%
Pruritus
10%
Anxiety
2%
Pleural Effusion
2%
Ileus
100%
80%
60%
40%
20%
0%
Study treatment Arm
Morphine Sulfate

Awards & Highlights

Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: MorphineExperimental Treatment1 Intervention
Morphine Sulfate: If weight is \<50 Kg; Morphine 0.1mg/kg IV to a maximum of 10mg can be given; if weight ≥ 50 Kg a maximum of 10mg can be given.
Group II: PlaceboPlacebo Group1 Intervention
Normal saline
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Morphine
FDA approved

Find a Location

Who is running the clinical trial?

University of Texas Southwestern Medical CenterLead Sponsor
1,078 Previous Clinical Trials
1,056,114 Total Patients Enrolled
Mercedes M Uribe, MDPrincipal InvestigatorUT Southwestern Medical Center
~0 spots leftby Oct 2025
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