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The Effect of Loop Diuretics on Severity and Outcome of Acute Kidney Injury

N/A
Waitlist Available
Led By Jay L Koyner, MD
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up during the index hospital stay, an average of 17 days, until hospital discharge, or until death, whatever occurs first
Awards & highlights
No Placebo-Only Group
Approved for 10 Other Conditions
All Individual Drugs Already Approved

Summary

This trial aims to use blood and urine tests to find indicators that can predict how severe Acute Kidney Injury (AKI) will become. It focuses on critically ill patients with AKI to help doctors foresee the need for dialysis or recovery chances.

Eligible Conditions
  • Acute Kidney Failure

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~during the index hospital stay, an average of 17 days, until hospital discharge, or until death, whatever occurs first
This trial's timeline: 3 weeks for screening, Varies for treatment, and during the index hospital stay, an average of 17 days, until hospital discharge, or until death, whatever occurs first for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Death
Progression to Stage 3 AKI
Receipt of Renal Replacement Therapy (RRT)
Secondary study objectives
Length of Hospital Stay
Length of Intensive Care Unit (ICU) Stay

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Trial Design

1Treatment groups
Experimental Treatment
Group I: LasixExperimental Treatment1 Intervention
Pt to get dose of furosemide after meeting entry criteria - dose dependent on previous exposure to diuretics
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Furosemide
FDA approved

Find a Location

Who is running the clinical trial?

University of ChicagoLead Sponsor
1,058 Previous Clinical Trials
765,500 Total Patients Enrolled
Jay L Koyner, MDPrincipal InvestigatorUniversity of Chicago
3 Previous Clinical Trials
507 Total Patients Enrolled
~6 spots leftby Dec 2025
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