HEPA Filters for Cardiometabolic Health

N/A

Recruiting

Led By Zhanghua Chen, PhD

Research Sponsored by University of Southern California

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at the baseline and immediately after each of the 6-month interventions

Summary

This trial tests if using HEPA filters can improve heart and metabolic health by reducing air pollution.

Who is the study for?

This trial is for people aged 65-84 living in Los Angeles County who are overweight (BMI ≥ 25 kg/m2 historically), non-smokers for at least a year, have Wi-Fi at home, and speak English or Spanish. It's not for those with active cancer treatment, plans to move soon, certain health conditions, homes unsuitable for air purifiers or already equipped with HEPA filters.

What is being tested?

The study tests if using HEPA filters in the home can improve heart and metabolic health by reducing fine particle pollution indoors. Participants will be randomly assigned to use either a real HEPA filter or a fake one without knowing which they have.

What are the potential side effects?

Since this trial involves the use of air filters rather than medication, there are no direct side effects from interventions like you would expect with drugs. However, changes in air quality could potentially affect respiratory symptoms.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at the baseline and immediately after each of the 6-month interventions

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at the baseline and immediately after each of the 6-month interventions

This trial's timeline: 3 weeks for screening, Varies for treatment, and at the baseline and immediately after each of the 6-month interventions for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in HOMA-IR

Change in HbA1c

Secondary study objectives

Change in blood pressure

Change in continuously monitored glucose level

Change in fasting glucose

+2 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: HEPA first and shamExperimental Treatment2 Interventions

This group of participants will be assigned an intervention of HEPA filters with the capacity to reduce PM2.5 levels at their residence for 6 months. After 6-month wash-out period, will be assigned to sham filters for 6 months.

Group II: Sham first and HEPAPlacebo Group2 Interventions

This group of participants will be assigned an intervention of sham filters without the capacity to reduce PM2.5 levels at their residence for 6 months. After 6-month wash-out period, will be assigned to HEPA filters for 6 months.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

HEPA filter

2016

N/A

~180

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