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EEG for Prediction Error in Anorexia

N/A
Waitlist Available
Led By Guido Frank, MD
Research Sponsored by University of California, San Diego
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Healthy body weight between 90 and 110 % average body weight.
Healthy body weight between 90 and 110 % average body weight
Must not have
Current Medications other than BCP or IUD
chronic obstructive pulmonary disease
Timeline
Screening 3 weeks
Treatment Varies
Follow Up immediate during brain scanning
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing the feasibility of using electroencephalography (EEG) to study adolescent anorexia nervosa (AN), with the goal of eventually replacing more costly and difficult-to-access fMRI.

Who is the study for?
This trial is for girls aged 11-17 with Anorexia Nervosa (AN), specifically the restricting type, and healthy controls within a similar age range. Participants must have a body weight below 17.5 BMI if diagnosed with AN or between 90-110% of average body weight if they are healthy controls. All participants should be right-handed as per the Edinburgh Handedness Inventory, speak English primarily, and for those with AN, be in their first weeks of treatment at specified centers.
What is being tested?
The study aims to develop an EEG-based method to investigate prediction error responses in adolescents with AN compared to healthy controls. It will adapt existing fMRI protocols for EEG use and test whether these can reliably measure brain responses related to reward processing errors across different stimuli like taste and money.
What are the potential side effects?
Since this trial involves non-invasive EEG testing rather than medication or invasive procedures, there are minimal expected side effects. The main concerns may include discomfort from wearing the EEG cap or stress from participating in the tasks required by the study.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My weight is within the normal range for my height.
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My weight is within the normal range for my height.
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I am diagnosed with anorexia, have a BMI under 17.5, fear gaining weight, see my body differently, and if applicable, haven't had a menstrual cycle for over three months.
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I am in my first 1-2 weeks of treatment at UC San Diego or Rady Children's Hospital.
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I am in my first 1-2 weeks of treatment at UC San Diego or Rady Children's Hospital.
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I am diagnosed with anorexia, have a BMI under 17.5, fear gaining weight, see my body differently, and if applicable, haven't had a menstrual cycle for over three months.
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I am a female between 11 and 17 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I am taking medications other than birth control pills or IUDs.
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I have chronic obstructive pulmonary disease.
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I am on medication to prevent blood clots.
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I have heart disease.
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I do not have any life-threatening conditions.
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I am paralyzed in my legs or in all four limbs.
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I am living with HIV/AIDS.
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I have a seizure disorder.
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I have sickle cell disease.
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I have severe asthma.
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I am legally blind.
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I have been diagnosed with schizophrenia or a similar psychotic disorder.
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I have been diagnosed with Alzheimer's disease or another form of dementia.
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A close family member has or had an eating disorder.
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I have never been diagnosed with bipolar disorder or psychosis.
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I am experiencing depression with thoughts of suicide.
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I have been diagnosed with Anorexia Nervosa.
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I have diabetes with complications like blindness or kidney failure.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~immediate during brain scanning
This trial's timeline: 3 weeks for screening, Varies for treatment, and immediate during brain scanning for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Electroencephalography
Monetary Reward Prediction Error Brain Response using EEG will show similar regional brain response compared to taste prediction error response.
Reward Prediction Error Brain Response using Electroencephalography (EEG) to separate healthy controls from individuals with anorexia nervosa.

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Healthy Control GroupExperimental Treatment1 Intervention
Participants who are considered to be healthy controls
Group II: Anorexia Nervosa GroupExperimental Treatment1 Intervention
Participants with anorexia nervosa

Find a Location

Who is running the clinical trial?

University of California, San DiegoLead Sponsor
1,180 Previous Clinical Trials
1,575,000 Total Patients Enrolled
18 Trials studying Anorexia Nervosa
1,858 Patients Enrolled for Anorexia Nervosa
Guido Frank, MDPrincipal Investigator - University of California, San Diego
University of California, San Diego
5 Previous Clinical Trials
431 Total Patients Enrolled
5 Trials studying Anorexia Nervosa
431 Patients Enrolled for Anorexia Nervosa

Media Library

Anorexia Nervosa Group Clinical Trial Eligibility Overview. Trial Name: NCT04583774 — N/A
Anorexia Nervosa Research Study Groups: Anorexia Nervosa Group, Healthy Control Group
Anorexia Nervosa Clinical Trial 2023: Anorexia Nervosa Group Highlights & Side Effects. Trial Name: NCT04583774 — N/A
Anorexia Nervosa Group 2023 Treatment Timeline for Medical Study. Trial Name: NCT04583774 — N/A
~0 spots leftby Dec 2024
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