Operant Conditioning for ACL Injury

N/A

Recruiting

Led By Chandramouli Krishnan, PhD

Research Sponsored by University of Michigan

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Suffered an acute, complete ACL rupture

Aged 18-45 years

Must not have

Have undergone previous major surgery to either knee

Be taking drugs that reduce seizure threshold

Timeline

Screening 3 weeks

Treatment Varies

Follow Up approximately 4 weeks after the start of intervention (mid-time point evaluation)

Awards & highlights

No Placebo-Only Group

Summary

This trial will study if operant conditioning can improve thigh muscle weakness and lack of muscle activation after an ACL injury.

Who is the study for?

This trial is for individuals aged 18-45 who have had an ACL rupture and subsequent reconstructive surgery. Participants must be willing to follow the study's procedures. Those pregnant, with previous major knee surgeries, on certain drugs, with fainting spells, uncontrolled diabetes or hypertension, ear/heart devices, recurrent headaches, seizures or recent significant knee injuries cannot join.

What is being tested?

The study tests if thigh muscle weakness post-ACL injury can be improved using mental coaching (operant conditioning) alongside Single Pulse Transcranial Magnetic Stimulation versus a control group without these interventions.

What are the potential side effects?

Potential side effects may include discomfort at the stimulation site from Transcranial Magnetic Stimulation and fatigue due to participation in operant conditioning sessions. No severe side effects are expected.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have a recent, complete tear in my ACL.

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I am between 18 and 45 years old.

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I have had ACL reconstructive surgery.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have had major surgery on one of my knees.

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I am taking medication that could lower my seizure threshold.

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I have diabetes or high blood pressure that is not well-controlled.

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I often have headaches for no known reason.

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I have had seizures recently.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ approximately 4 weeks after the start of intervention (mid-time point evaluation)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~approximately 4 weeks after the start of intervention (mid-time point evaluation)

This trial's timeline: 3 weeks for screening, Varies for treatment, and approximately 4 weeks after the start of intervention (mid-time point evaluation) for reporting.