The Diagnostic Ultrasound Enthesitis Tool (DUET) Study
(DUET Trial)

Recruiting in Palo Alto (17 mi)

Overseen byGurjit S Kaeley, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Women's College Hospital

No Placebo Group

Trial Summary

What is the purpose of this trial?

Psoriatic arthritis (PsA) is a type of joint disease that can lead to severe joint damage and disability within the first few years of the disease. This is why early detection and treatment of the disease is essential to prevent serious joint damage and improve long-term outcomes in these patients. However, there is currently no reliable way to tell the difference between PsA and other types of joint disease. This makes it difficult to detect PsA early. Enthesitis is an inflammation of the area where muscle tendons and ligaments attach to bones. Enthesitis is a key feature in PsA and can be easily detected using ultrasonography. The aim of this research study is to develop a system to evaluate enthesitis using ultrasonography, which can be used as an effective tool in the early detection of PsA. This will help in providing patients with early treatment to prevent further joint damage.

Research Team

Lihi Eder, MD, PhD

Principal Investigator

University of Toronto

Sibel Z Aydin, MD

Principal Investigator

University of Ottawa

Gurjit S Kaeley, MD

Principal Investigator

University of Florida

Eligibility Criteria

Inclusion Criteria

Age ≥18

Able to provide an informed consent

Early PsA - Less than 5 years from a rheumatologist diagnosis of PsA

See 7 more

Treatment Details

Interventions

Musculoskeletal Ultrasound (Diagnostic Test)

Participant Groups

3Treatment groups

Experimental Treatment

Group I: Psoriatic ArthritisExperimental Treatment1 Intervention

Subjects newly diagnosed with psoriatic arthritis (\< 5 years), confirmed by a rheumatologist and fulfilling the ClASsification for Psoriatic ARthritis (CASPAR) criteria.

Group II: Psoriasis without musculoskeletal symptomsExperimental Treatment1 Intervention

Patients with dermatologist confirmed psoriasis, without any history of Psoriatic Arthritis, and musculoskeletal symptoms.

Group III: Non-Inflammatory Rheumatic conditionsExperimental Treatment1 Intervention

Patients with non-inflammatory rheumatic conditions such as osteoarthritis, non-specific back pain, soft tissue rheumatism, degenerative tendinopathy and fibromyalgia. Patients with present or past history of psoriasis, psoriatic arthritis, known or suspected rheumatic inflammatory conditions (e.g. rheumatoid arthritis, spondyloarthritis and gout), and/or inflammatory bowel disease will be excluded.