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Exercise Training for Atrial Fibrillation

N/A
Waitlist Available
Led By Jennifer L Reed, PhD
Research Sponsored by Ottawa Heart Institute Research Corporation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
At least 40 years of age
Persistent or permanent atrial fibrillation
Must not have
Uncontrolled diabetes mellitus
Diagnosed severe mitral or aortic stenosis
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to 12 weeks
Awards & highlights
No Placebo-Only Group

Summary

This trial will compare the effects of high-intensity interval training vs. moderate-intensity continuous exercise training in adults with persistent or permanent atrial fibrillation on exercise capacity and quality of life.

Who is the study for?
This trial is for adults over 40 with persistent or permanent atrial fibrillation, a resting heart rate of 110 bpm or less, and able to do an exercise test. They must not be already exercising regularly, have unstable angina, certain heart conditions like obstructive cardiomyopathy or severe valve stenosis, uncontrolled diabetes, and must agree to sign informed consent.
What is being tested?
The study compares two types of exercise programs for people with atrial fibrillation: high-intensity interval training (short bursts of intense activity) versus moderate-intensity continuous training (steady activity). It aims to see which one better improves exercise capacity and quality of life.
What are the potential side effects?
Exercise may cause shortness of breath, fatigue, muscle soreness or injury. High-intensity interval training can be more demanding on the heart; participants are monitored closely for any adverse effects related to their condition.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 40 years old or older.
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I have ongoing or permanent irregular heartbeat.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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My diabetes is not well-managed.
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I have been diagnosed with severe narrowing of my heart's mitral or aortic valve.
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I have been diagnosed with a thickened heart muscle that obstructs blood flow.
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I have unstable chest pain.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to 12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 12 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in exercise capacity as measured by six-minute walk test distance
Change in quality of life as measured by the Short-Form 36 questionnaire
Secondary study objectives
Change in activity status measured by the Duke Activity Status Index
Change in anxiety and depressive symptoms will be measured using the Hospital Anxiety and Depression Scale (HADS)
Change in disease specific quality of life will be measured using the University of Toronto Atrial Fibrillation Severity Scale (AFSS)
+9 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Moderate-intensity continuous exerciseExperimental Treatment1 Intervention
Moderate-intensity continuous exercise training
Group II: High-Intensity Interval TrainingExperimental Treatment1 Intervention
High-Intensity Interval Training
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
high-intensity interval training
2009
N/A
~270

Find a Location

Who is running the clinical trial?

Ottawa Heart Institute Research CorporationLead Sponsor
196 Previous Clinical Trials
93,574 Total Patients Enrolled
24 Trials studying Atrial Fibrillation
6,952 Patients Enrolled for Atrial Fibrillation
Jennifer L Reed, PhDPrincipal InvestigatorOttawa Heart Institute Research Corporation
6 Previous Clinical Trials
531 Total Patients Enrolled
4 Trials studying Atrial Fibrillation
356 Patients Enrolled for Atrial Fibrillation

Media Library

high-intensity interval training Clinical Trial Eligibility Overview. Trial Name: NCT02602457 — N/A
Atrial Fibrillation Research Study Groups: Moderate-intensity continuous exercise, High-Intensity Interval Training
Atrial Fibrillation Clinical Trial 2023: high-intensity interval training Highlights & Side Effects. Trial Name: NCT02602457 — N/A
high-intensity interval training 2023 Treatment Timeline for Medical Study. Trial Name: NCT02602457 — N/A
~33 spots leftby Jan 2030
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