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Speech Tasks for Understanding Brain Processing of Language

N/A

Waitlist Available

Led By Edward F Chang, MD

Research Sponsored by University of California, San Francisco

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Must not have

Participants with cognitive deficits that preclude reliable completion of study tasks.

Participants who lack capacity or decline to provide informed consent

Timeline

Screening 3 weeks

Treatment Varies

Follow Up between 10-30 minutes

Awards & highlights

No Placebo-Only Group

Summary

This trial is studying how the human brain extracts linguistic elements from speech. They will be recording neural activity from people speaking different languages to try and understand how the brain processes speech.

Who is the study for?

This trial is for individuals at UCSF with epilepsy or brain tumors who are undergoing surgery involving electrode implantation. They must be able to perform study tasks and have electrodes in at least two key brain areas. Those unable to consent, with significant cerebral lesions, or cognitive deficits that prevent task completion cannot participate.

What is being tested?

The study aims to understand how the brain processes speech across different languages by recording neural activity during surgery. It uses high-density electrodes and signal processing on patients speaking Mandarin, Spanish, and English to explore phonetic encoding in the temporal cortex.

What are the potential side effects?

Since this research involves non-invasive observation of neural activity during a surgical procedure already planned for other medical reasons, there are no additional side effects directly associated with the trial's interventions.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am able to understand and complete study tasks without difficulty.

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I am unable or unwilling to give consent for this trial.

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I have significant brain lesions.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ between 10-30 minutes

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~between 10-30 minutes

This trial's timeline: 3 weeks for screening, Varies for treatment, and between 10-30 minutes for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Number of Participants with Electrocorticography (ECoG) Signals for Neural Activity Identified During Intraoperative Procedure or Inpatient Hospitalization

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Electrocorticography (ECoG) recording during Speech TasksExperimental Treatment1 Intervention

Participants listened to 20-minute Speech Tasks while ECoG signals for neural activity was recorded during their intraoperative procedure or inpatient hospitalization at the University of California, San Francisco (UCSF).

0 / 3Eligibility criteria met