Streptomycin Sulfate

Plague, Chancroid, Tularemia + 13 more

Treatment

10 FDA approvals

20 Active Studies for Streptomycin Sulfate

Treatment for

Plague

What is Streptomycin Sulfate

StreptomycinThe Generic name of this drug

Treatment SummaryStreptomycin is an antibiotic made from a soil bacterium called Streptomyces griseus. It was discovered in the 1940s and its antibacterial effects earned its discoverers the Nobel Prize in Medicine. While it was once commonly used to treat tuberculosis, its use has since declined due to the development of resistance. It is now mainly used as a secondary treatment for multi-drug resistant tuberculosis.

Streptomycin Sulfateis the brand name

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Streptomycin Sulfate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Streptomycin Sulfate

Streptomycin

1952

Approved as Treatment by the FDA

Streptomycin, otherwise called Streptomycin Sulfate, is approved by the FDA for 10 uses which include Pneumonia and Influenza .

Pneumonia

Influenza

Urinary Tract Infections

Chancroid

Tuberculosis

Used to treat Tuberculosis (TB) in combination with Isoniazid

Bacterial Infections

Bacteremia

Plague

Granuloma Inguinale

Tularemia

Effectiveness

How Streptomycin Sulfate Affects PatientsStreptomycin is an antibiotic that is used to treat certain bacteria, including Yersinia pestis, Francisella tularensis, Brucella, H. ducreyi, and H. influenza. It is less effective against the bacteria Pseudomonas aeruginosa. Taking streptomycin may lead to hearing loss and vestibular dysfunction, as well as kidney and muscle damage. People taking this drug should be watched carefully for signs of these side effects.

How Streptomycin Sulfate works in the bodyAminoglycosides work to kill bacteria in two ways. First, they bind to bacterial cell membranes, creating holes in and damaging them. This immediately kills the bacteria. Second, they bind to the bacteria's ribosomes and stop proteins from being produced correctly. This eventually leads to the bacteria dying, but takes longer. The aminoglycosides bind to two sites on the ribosome - one near the A site, and one near the 23S rRNA - and stop it from making proteins correctly. As a result, incorrect proteins are made and the cell membrane is damaged, which eventually kills the bacteria.

When to interrupt dosage

The advised dosage of Streptomycin Sulfate is subject to the diagnosed condition, including Tuberculosis (TB), Influenza and Plague. The measure of dosage fluctuates as detailed in the table below, contingent upon the technique of administration (e.g. Liquid - Intramuscular or Liquid).

Condition

Dosage

Administration

Mycobacterium kansasii infection

1000.0 mg, , 1000.0 mg/mL

, Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Liquid - Intramuscular, Liquid, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular

Acrodynia

1000.0 mg, , 1000.0 mg/mL

Mycobacterium marinum infection

1000.0 mg, , 1000.0 mg/mL

Influenza

1000.0 mg, , 1000.0 mg/mL

Chancroid

1000.0 mg, , 1000.0 mg/mL

Pneumonia

1000.0 mg, , 1000.0 mg/mL

Urinary Tract Infections

1000.0 mg, , 1000.0 mg/mL

Bacterial Infections

1000.0 mg, , 1000.0 mg/mL

Plague

1000.0 mg, , 1000.0 mg/mL

Tuberculosis

1000.0 mg, , 1000.0 mg/mL

Tularemia

1000.0 mg, , 1000.0 mg/mL

Bacteremia

1000.0 mg, , 1000.0 mg/mL

Mycobacterium avium complex infection

1000.0 mg, , 1000.0 mg/mL

Granuloma Inguinale

1000.0 mg, , 1000.0 mg/mL

Disseminated mycobacterium avium complex infection

1000.0 mg, , 1000.0 mg/mL

HIV

1000.0 mg, , 1000.0 mg/mL

Warnings

Streptomycin Sulfate has two contraindications and must not be taken in coalition with the disorders specified in the table below.Streptomycin Sulfate Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Streptomycin may interact with Pulse Frequency

There are 20 known major drug interactions with Streptomycin Sulfate.

Common Streptomycin Sulfate Drug Interactions

Drug Name

Risk Level

Description

Neomycin

Major

The risk or severity of nephrotoxicity can be increased when Streptomycin is combined with Neomycin.

Tenofovir

Major

Streptomycin may increase the nephrotoxic activities of Tenofovir.

Tenofovir alafenamide

Major

Streptomycin may increase the nephrotoxic activities of Tenofovir alafenamide.

Tenofovir disoproxil

Major

Streptomycin may increase the nephrotoxic activities of Tenofovir disoproxil.

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Streptomycin.

Streptomycin Sulfate Toxicity & Overdose RiskOverdosing on streptomycin can lead to hearing or balance problems, as well as kidney damage. Symptoms of kidney damage may range from mild, such as increased levels of urea in the blood and protein in the urine, to more severe cases of permanent hearing loss and vestibular dysfunction. If a patient has overdosed on streptomycin, their serum concentration can be reduced through dialysis.

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Streptomycin Sulfate Novel Uses: Which Conditions Have a Clinical Trial Featuring Streptomycin Sulfate?

244 active clinical trials are presently studying the potential of Streptomycin Sulfate in combating Bacterial Infections caused by susceptible bacteria, Mycobacterium avium complex infection and Granuloma Inguinale.

Condition

Clinical Trials

Trial Phases

Granuloma Inguinale

0 Actively Recruiting

Acrodynia

1 Actively Recruiting

Phase 2

Mycobacterium kansasii infection

0 Actively Recruiting

Mycobacterium avium complex infection

3 Actively Recruiting

Phase 2, Phase 3

Plague

0 Actively Recruiting

Tularemia

0 Actively Recruiting

Mycobacterium marinum infection

0 Actively Recruiting

Bacteremia

4 Actively Recruiting

Phase 4, Phase 1, Phase 2, Not Applicable

Disseminated mycobacterium avium complex infection

0 Actively Recruiting

Pneumonia

21 Actively Recruiting

Not Applicable, Phase 3, Phase 2, Phase 1

Tuberculosis

3 Actively Recruiting

Not Applicable, Phase 3, Phase 2

Chancroid

0 Actively Recruiting

Bacterial Infections

0 Actively Recruiting

Urinary Tract Infections

4 Actively Recruiting

Not Applicable

Influenza

34 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 3, Phase 1

HIV

128 Actively Recruiting

Phase 2, Phase 1, Not Applicable, Phase 3, Phase 4, Early Phase 1

Patient Q&A Section about streptomycin sulfate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is streptomycin sulfate the same as streptomycin?

"The sulfate salt form of streptomycin is an aminoglycoside antibiotic that is derived from Streptomyces griseus and has antibacterial properties."

Answered by AI

What type of antibiotic is streptomycin?

"Streptomycin is an aminoglycoside antibiotic that was first isolated from the bacteria Streptomyces griseus. It is now primarily used as part of the multi-drug treatment of pulmonary tuberculosis. It has additional activity against several aerobic gram-negative bacteria."

Answered by AI

What is streptomycin sulfate used for?

"This antibiotic is used to treat certain types of bacterial infections, however it will not work against infections like colds or the flu. If you have any questions about other purposes for this medicine, ask your health care provider or pharmacist."

Answered by AI

What bacteria is killed by streptomycin?

"Streptomycin is a medication used to treat bacterial infections, including tuberculosis, Mycobacterium avium complex, endocarditis, brucellosis, Burkholderia infection, plague, tularemia, and rat bite fever."

Answered by AI

Clinical Trials for Streptomycin Sulfate

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Have you considered Streptomycin Sulfate clinical trials? We made a collection of clinical trials featuring Streptomycin Sulfate, we think they might fit your search criteria.

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Behavioral Nudges for Flu Shot Uptake

18+

All Sexes

Lancaster, PA

This trial will test if personalized reminders to both doctors and patients can increase flu vaccination rates in older adults. The study will last for 6 months and will involve sending text message reminders to patients before their

Waitlist Available

Has No Placebo

Lancaster General HealthShivan Mehta, MD, MBA, MSHP

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CD388 Injection for Flu Prevention

18 - 63

All Sexes

Cullman, AL

This trial aims to find the right amount of CD388 that can prevent the flu compared to a placebo. The study will involve giving three injections under the skin to healthy adults and will also look at the

Phase 2

Recruiting

Cullman Clinical Trials (+55 Sites)Taylor Sandison, MD, MPHCidara Therapeutics Inc.

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Text Message Reminders for Pediatric COVID-19 and Flu Vaccines

6 - 17

All Sexes

Itasca, IL

This trial is looking at how text message reminders can help people get their COVID-19 and flu vaccines. It is being done in various pediatric practices associated with the American Academy of Pediatrics.

Waitlist Available

Has No Placebo

American Academy of Pediatrics (+3 Sites)Alex Fiks, MD MSCE

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COVID-19 Booster + Flu Vaccine for Immunocompromised People

18+

All Sexes

Montréal, Canada

"This trial aims to find the best way to boost the immune response in people with weakened immune systems. They want to see if getting the COVID-19 booster shot along with the flu vaccine at the same

Phase 2

Waitlist Available

Has No Placebo

Research Institute of McGill University Health Centre

Have you considered Streptomycin Sulfate clinical trials? We made a collection of clinical trials featuring Streptomycin Sulfate, we think they might fit your search criteria.

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Text Message Reminders for Flu Vaccination

6 - 18

All Sexes

Philadelphia, PA

This trial will test if sending text message reminders can improve flu vaccination rates for children, whether they have a scheduled doctor's visit or not, at the Children's Hospital of Philadelphia Care Network. This

Recruiting

Has No Placebo

The Children's Hospital of PhiladelphiaBrian P. Jenssen, MD

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Antibody Treatment for HIV

18 - 60

All Sexes

Bethesda, MD

"This trial is testing a new product called CAP256J3LS, which uses antibodies to potentially prevent HIV infections. The objective is to see if this new product is safe for healthy individuals aged 18

Phase 1

Recruiting

Has No Placebo

National Institutes of Health Clinical CenterJoseph P Casazza, M.D.

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PrTNER Program for HIV Prevention

15 - 24

Male

Baltimore, MD

"This trial aims to see if a new program called PrTNER can help young Black and Latino men who have sex with men to start taking PrEP to prevent HIV and reduce the levels of HIV in

Waitlist Available

Has No Placebo

Johns Hopkins Center for Adolescent and Young Adult Health (+1 Sites)Renata Sanders, MD

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Nudge Communication for Flu Vaccination

18+

All Sexes

Pleasanton, CA

This trial is looking at how to increase flu vaccination rates among Kaiser Permanente members. Getting the flu shot can help reduce flu-related illnesses and hospitalizations, as well as potentially lower the risk of

Recruiting

Has No Placebo

Kaiser Permanente Northern California (+1 Sites)Natalia Berry, MD

Have you considered Streptomycin Sulfate clinical trials? We made a collection of clinical trials featuring Streptomycin Sulfate, we think they might fit your search criteria.