What side effects are associated with this type of intervention?

Common treatments for breast cancer, including ultrasound-guided biopsy, surgery, radiation therapy, and endocrine therapy, have various side effects. Ultrasound-guided biopsy is generally well-tolerated but can cause localized pain, bleeding, and infection at the biopsy site. Surgery, such as lumpectomy or mastectomy, may lead to pain, swelling, scarring, and risk of infection. Radiation therapy can cause skin irritation, fatigue, and long-term changes in breast tissue. Endocrine therapies, like tamoxifen or aromatase inhibitors, often result in hot flashes, joint pain, and increased risk of bone density loss. Patients should discuss these potential side effects with their healthcare provider to manage and mitigate them effectively.

What prior FDA approvals exist?

The FDA has approved several treatments for breast cancer, including targeted therapies, hormone therapies, and chemotherapies. Notable approvals include trastuzumab (Herceptin) for HER2-positive breast cancer, which targets the HER2 protein on cancer cells, and palbociclib (Ibrance), a CDK4/6 inhibitor used in combination with hormone therapy for HR-positive, HER2-negative breast cancer. Additionally, the use of ultrasound-guided biopsy is a common practice to obtain tissue samples for diagnostic purposes, aiding in the selection of appropriate targeted therapies based on the tumor's specific characteristics.

What other types of research exist?

Promising novel alternatives to ultrasound-guided biopsy for breast cancer patients include MRI-guided biopsy, which offers high-resolution imaging and better lesion characterization, and liquid biopsy, which analyzes circulating tumor DNA in the blood for non-invasive cancer detection and monitoring. These methods provide enhanced diagnostic accuracy and may reduce the need for invasive tissue sampling.

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Ultrasound-Guided Biopsy for Breast Cancer

N/A

Waitlist Available

Led By Henry Kuerer, MD, PHD

Research Sponsored by M.D. Anderson Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 day

Awards & highlights

No Placebo-Only Group

Summary

This trial compares a method using ultrasound to collect cells or tissue from tumors with results from surgery to see if the method can accurately detect disease in patients with tumors.

Who is the study for?

This trial is for adults over 18 with a specific type of breast cancer (either triple negative or HER2 amplified) at various stages. Participants are those who have received preoperative therapy and are planning to undergo surgery.

What is being tested?

The study is examining the effectiveness of using ultrasound-guided biopsy to detect breast cancer compared to traditional surgical methods. It aims to see if this less invasive technique can reliably find evidence of disease.

What are the potential side effects?

Since the intervention being studied is an ultrasound-guided biopsy, potential side effects may include discomfort, bruising, bleeding at the biopsy site, and very rarely infection.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 day

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 day

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 day for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Diagnostic Accuracy of Ultrasound-Guided FNA and Core Biopsy of Initial Breast Cancer Region Compared to Standard Surgery with Pathologic Evaluation

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Ultrasound-Guided Biopsy of Tumor SiteExperimental Treatment1 Intervention

Ultrasound-guided biopsy of the tumor site performed before scheduled surgery.

Do I qualify?Apply below to find out

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for breast cancer include surgery, radiation therapy, chemotherapy, hormone therapy, and targeted therapy. Surgery involves the physical removal of the tumor, which is essential for reducing the cancer burden. Radiation therapy uses high-energy rays to kill cancer cells and shrink tumors, helping to prevent recurrence. Chemotherapy employs drugs to destroy rapidly dividing cancer cells throughout the body. Hormone therapy blocks hormones like estrogen that fuel certain types of breast cancer, thereby slowing or stopping tumor growth. Targeted therapy focuses on specific molecules involved in cancer cell growth and survival, offering a more precise treatment approach. These treatments are critical for breast cancer patients as they provide multiple strategies to combat the disease, improve survival rates, and enhance quality of life. Ultrasound-guided biopsy, while not a treatment, is a diagnostic tool that helps in accurately identifying the nature of the breast lesion, guiding appropriate treatment decisions.

Intratumoral Agreement of High-Resolution Magic Angle Spinning Magnetic Resonance Spectroscopic Profiles in the Metabolic Characterization of Breast Cancer.