Your session is about to expire
← Back to Search
DWI/MRI for Detecting Colorectal and Appendiceal Cancer (DWI-HighRisk Trial)
N/A
Waitlist Available
Led By Alexandre Brind'Amour, MD
Research Sponsored by Laval University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 36 months
Awards & highlights
No Placebo-Only Group
Summary
This trial aims to evaluate how well DWI/MRI detects PM in people with CRC or AN who have a high risk of recurrence. It will compare DWI/MRI to CT and laparoscopy to see which works best.
Who is the study for?
This trial is for patients with high-risk colorectal or appendiceal cancers without distant metastases, who are fit enough for potential surgery (ECOG 0 or 1), and have features indicating a risk of peritoneal recurrence. It's not for those unable to undergo MRI, unfit for surgery (ECOG 2+), with low-grade tumors, or unresected synchronous peritoneal metastases.
What is being tested?
The study tests the effectiveness of whole-body diffusion-weighted magnetic resonance imaging (WB-DWI/MRI) in detecting peritoneal metastases during follow-up of high-risk colorectal and appendiceal cancer patients. It compares this method to CT scans and diagnostic laparoscopy.
What are the potential side effects?
Since the intervention involves MRI scanning, there are generally no direct side effects like you would expect from drugs; however, some individuals may experience discomfort due to the enclosed space of the MRI machine.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 36 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~36 months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Early peritoneal recurrence
Peritoneal findings
Secondary study objectives
Early distant recurrence
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: DWI-High RiskExperimental Treatment1 Intervention
Patients to undergo DWI-MRI (patients included in the study).
Find a Location
Who is running the clinical trial?
Laval UniversityLead Sponsor
434 Previous Clinical Trials
178,608 Total Patients Enrolled
Ciusss de L'Est de l'Île de MontréalOTHER
78 Previous Clinical Trials
6,385 Total Patients Enrolled
Alexandre Brind'Amour, MDPrincipal InvestigatorLaval University
2 Previous Clinical Trials
51 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- My cancer has not spread to distant parts of my body.I have a low-grade tumor in my appendix.I have cancer spread to the lining of my abdomen that hasn't been surgically removed.I am not fit for major surgery due to my physical condition.My scans and surgery reports show no remaining cancer in my abdomen.My condition does not have a high risk of recurring in the abdomen lining.I am fit for surgery to remove as much cancer as possible (ECOG 0 or 1).My scans show cancer has spread to distant parts of my body.I have been diagnosed with colorectal cancer or a serious type of appendiceal cancer.I had surgery to remove cancer that spread to my abdomen or ovaries, or my cancer caused a hole in my intestine.
Research Study Groups:
This trial has the following groups:- Group 1: DWI-High Risk
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.