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DWI/MRI for Detecting Colorectal and Appendiceal Cancer (DWI-HighRisk Trial)

N/A
Waitlist Available
Led By Alexandre Brind'Amour, MD
Research Sponsored by Laval University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 36 months
Awards & highlights
No Placebo-Only Group

Summary

This trial aims to evaluate how well DWI/MRI detects PM in people with CRC or AN who have a high risk of recurrence. It will compare DWI/MRI to CT and laparoscopy to see which works best.

Who is the study for?
This trial is for patients with high-risk colorectal or appendiceal cancers without distant metastases, who are fit enough for potential surgery (ECOG 0 or 1), and have features indicating a risk of peritoneal recurrence. It's not for those unable to undergo MRI, unfit for surgery (ECOG 2+), with low-grade tumors, or unresected synchronous peritoneal metastases.
What is being tested?
The study tests the effectiveness of whole-body diffusion-weighted magnetic resonance imaging (WB-DWI/MRI) in detecting peritoneal metastases during follow-up of high-risk colorectal and appendiceal cancer patients. It compares this method to CT scans and diagnostic laparoscopy.
What are the potential side effects?
Since the intervention involves MRI scanning, there are generally no direct side effects like you would expect from drugs; however, some individuals may experience discomfort due to the enclosed space of the MRI machine.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~36 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 36 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Early peritoneal recurrence
Peritoneal findings
Secondary study objectives
Early distant recurrence

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: DWI-High RiskExperimental Treatment1 Intervention
Patients to undergo DWI-MRI (patients included in the study).

Find a Location

Who is running the clinical trial?

Laval UniversityLead Sponsor
430 Previous Clinical Trials
178,365 Total Patients Enrolled
Ciusss de L'Est de l'Île de MontréalOTHER
77 Previous Clinical Trials
6,313 Total Patients Enrolled
Alexandre Brind'Amour, MDPrincipal InvestigatorLaval University
2 Previous Clinical Trials
51 Total Patients Enrolled

Media Library

DWI-High Risk Clinical Trial Eligibility Overview. Trial Name: NCT05623787 — N/A
Appendiceal Neoplasm Research Study Groups: DWI-High Risk
Appendiceal Neoplasm Clinical Trial 2023: DWI-High Risk Highlights & Side Effects. Trial Name: NCT05623787 — N/A
DWI-High Risk 2023 Treatment Timeline for Medical Study. Trial Name: NCT05623787 — N/A
~0 spots leftby Dec 2024
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