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Meal Timing for Metabolism

N/A

Waitlist Available

Led By Eve Van Cauter, PhD

Research Sponsored by University of Chicago

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

aged 30-75 years

Be older than 18 years old

Must not have

Females with a hemoglobin < 11.5g/dL, and males with a hemoglobin < 13.5 g/dl will be excluded from the study

Female subjects must not be actively going through menopause

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 15 days

Awards & highlights

No Placebo-Only Group

Summary

This trial will study how the timing of meals affects metabolism and if metabolism changes with age.

Who is the study for?

This trial is for healthy overweight or obese adults aged 30-75 with a BMI between 25 and less than 40, who sleep between 6.5 to 9 hours nightly within specific hours. Excluded are those with dietary restrictions, certain blood conditions, diabetes, unstable medical issues, recent surgeries or clinical study participation, menopause or pregnancy in women, and various medication uses.

What is being tested?

The study investigates how eating times affect body metabolism and energy use. Participants will follow different schedules of caloric intake: early total intake versus late intake and an extended overnight fast to see if these factors influence metabolic changes as people age.

What are the potential side effects?

Since the interventions involve meal timing rather than medications or invasive procedures, side effects may include hunger at unusual times of day or discomfort from changing usual eating patterns but are not expected to be severe.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 30 and 75 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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My hemoglobin level is above 11.5g/dL if female, or above 13.5g/dL if male.

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I am not currently going through menopause.

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I am unable to give consent by myself.

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I have a diagnosed sleep disorder like severe sleep apnea or a circadian rhythm issue.

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I do not have any serious or unstable health conditions.

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I have been diagnosed with diabetes.

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I have had weight loss surgery.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 15 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~15 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and 15 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

MI-IS

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: Late Total Caloric IntakeExperimental Treatment1 Intervention

The Late Total Caloric Intake study group will have scheduled meal times for the entire 6 day semi ambulatory and in lab session and will consume 40% of daily calories during breakfast and lunch. The remaining 60% of daily calories will be consumed during dinner. This is a model for late dietary chronotype.

Group II: Early Total Caloric IntakeExperimental Treatment1 Intervention

The Early Total Caloric Intake study group will have scheduled meal times for the entire 6 day semi ambulatory and in lab session and will consume 60% of their daily calories during breakfast. The remaining 40% of daily calories will be consumed during lunch and dinner. This is a model for early dietary chronotype.

Group III: Extended Overnight FastActive Control1 Intervention

The extended overnight fast group will have scheduled meal times for the entire 6 day semi ambulatory and in lab session. Subjects will consume approximately 33% of their daily calories at breakfast, lunch and dinner, respectively. This is a model for fasting dietary chronotype.

0 / 8Eligibility criteria met