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Neuromodulation

Electrical Stimulation for Cerebral Palsy

N/A

Recruiting

Led By Max J Kurz, PhD

Research Sponsored by Father Flanagan's Boys' Home

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

For Cerebral Palsy Participants: Gross Motor Function Classification score (GMFCS) levels between I-IV

Be younger than 65 years old

Must not have

For Cerebral Palsy Participants: No orthopedic surgery in the last 6 months or metal in their body that would preclude the use of an MRI

For Neurotypical Controls: No orthopedic surgery in the last 6 months or metal in their body that would preclude the use of an MRI

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 30 minutes

Awards & highlights

No Placebo-Only Group

Summary

"This trial aims to study the differences in brain and spinal cord activity in individuals with cerebral palsy compared to those without. The study will also look at the effects of a type of electrical stimulation on brain

Who is the study for?

This trial is for individuals with Cerebral Palsy. It aims to understand and potentially improve how their brain and spinal cord work together. Participants should be able to undergo various non-invasive imaging tests like fMRI and MEG, as well as receive transcutaneous current stimulation.

What is being tested?

The study is testing whether applying a mild electrical current over the skin (transcutaneous current stimulation) can change brain and spinal cord activity in people with CP. It includes detailed assessments of these activities using advanced imaging techniques.

What are the potential side effects?

Transcutaneous current stimulation may cause discomfort or skin irritation at the site of application. Imaging procedures are generally safe but may require participants to remain still for extended periods.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My cerebral palsy affects my movement but I can still move with or without aids.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I haven't had orthopedic surgery in the last 6 months and have no metal implants that would interfere with an MRI.

Select...

I haven't had orthopedic surgery in the last 6 months and have no metal implants that would interfere with an MRI.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 30 minutes

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~30 minutes

This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 minutes for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Measure - Hoffman Reflex Assessments

Measure - MEG Brain Imaging

Measure - Transcutaneous Current Stimulation

+2 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Neurotypical Youth/AdultsExperimental Treatment5 Interventions

Compared with the sham controls, those receiving the transcutaneous current stimulation will demonstrate alterations in the strength of the sensorimotor cortical activity, spinal cord activity, and corticospinal coherence. Moreover, the extent of the alterations in the sensorimotor cortical activity, spinal cord activity, and corticospinal coherence will be tightly linked with the clinical presentations of persons with CP.

Group II: Cerebral Palsy Youth/AdultsExperimental Treatment5 Interventions

0 / 3Eligibility criteria met