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Anesthesia's Impact on Neurocognitive Function After Concussion

N/A

Waitlist Available

Led By Arnoley S Abcejo, MD

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Must not have

Neurologic history including history of severe cognitive disease, disorder, or delay

History of neurovascular order or trauma.

Timeline

Screening 3 weeks

Treatment Varies

Follow Up post-operatively to hospital discharge, up to 10 days.

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing if anesthesia affects the brain differently in people who have had a concussion.

Who is the study for?

This trial is for men and women over the age of 16 who have had a concussion within the last 10 weeks and are scheduled for a procedure that requires anesthesia. It's not open to those with severe cognitive diseases, moderate to severe traumatic brain injury (TBI), attention disorders, or past neurovascular trauma.

What is being tested?

The study aims to assess how anesthesia and surgery might affect brain function after a recent concussion. Participants will undergo neurocognitive testing before and after their procedures to measure any changes.

What are the potential side effects?

Since this trial involves standard medical procedures rather than new medications, side effects are related to typical risks associated with anesthesia such as nausea, drowsiness, sore throat, confusion or memory issues post-surgery.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have a history of severe cognitive or neurological conditions.

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I have had a stroke or brain injury.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ post-operatively to hospital discharge, up to 30 days.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~post-operatively to hospital discharge, up to 30 days.

This trial's timeline: 3 weeks for screening, Varies for treatment, and post-operatively to hospital discharge, up to 30 days. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Wide Range Achievement Test Fourth Edition, WRAT-4

Secondary study objectives

Cognitive Deficits identified by NeuroPsychometric Cognitive Testing

Length of hospital stay

Numeric Pain Scale 0-10

+2 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Matched Subjects GroupExperimental Treatment1 Intervention

Matched subjects without concussion undergoing a planned surgery/anesthetic standard of care, matching for procedural type, sex, age ± 2 years, and adherence to the exclusion criteria will undergo neurocognitive testing pre and post surgery/anesthetic.

Group II: Concussion GroupExperimental Treatment1 Intervention

Subjects diagnosed with concussion defined as a clinician-diagnosed disease by the International Classification of Diseases (ICD)-10 due to a head injury with a Glasgow Coma Score ≥13 undergoing a planned surgery/anesthetic standard of care will undergo neurocognitive testing pre and post surgery/anesthetic.

0 / 2Eligibility criteria met