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Comprehensive Sequencing

Deep Sequencing Test for Intraocular Infections (OPTICS Trial)

N/A
Recruiting
Led By Thuy Doan, MD, PhD
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Presumed infectious anterior uveitis, intermediate uveitis, posterior uveitis, or panuveitis
Presumed post-operative endophthalmitis
Must not have
Unable to consent
Age less than 18 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4-week after randomization
Awards & highlights
No Placebo-Only Group

Summary

This trial is designed to compare the effectiveness of a new deep sequencing test for intraocular infections versus the current standard of care test. Patients who receive the new test will be compared to those who do not to see if there are improved outcomes.

Who is the study for?
This trial is for adults over 18 with suspected infectious uveitis or post-operative endophthalmitis, which are types of eye infections. It's not suitable for those who can't consent, don't have enough specimen for MDS testing, are under 18, or are pregnant.
What is being tested?
The study compares the effectiveness of Metagenomic Deep Sequencing (MDS) to standard tests in improving treatment outcomes for eye infections. Participants will be randomly assigned to either receive MDS test results or not alongside regular care.
What are the potential side effects?
Since this trial focuses on diagnostic methods rather than treatments, side effects aren't a primary concern. However, there may be general risks associated with collecting specimens required for MDS.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have an eye infection affecting the front, middle, back, or all parts of my eye.
Select...
I am suspected to have an eye infection after surgery.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I am unable to give consent by myself.
Select...
I am under 18 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4-week after randomization
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4-week after randomization for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Appropriate therapy
Clinical improvement
Secondary study objectives
Infection status
Patient quality of life
Provider certainty of belief
+1 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: MDSExperimental Treatment1 Intervention
Patients enrolled in the trial and randomized to the MDS arm will undergo standard of care testing and MDS testing.
Group II: Standard of CareActive Control1 Intervention
Patients enrolled in the trial and randomized to the standard of care (SOC) arm will undergo standard of care testing.

Find a Location

Who is running the clinical trial?

University of California, Los AngelesOTHER
1,566 Previous Clinical Trials
10,263,354 Total Patients Enrolled
University of UtahOTHER
1,141 Previous Clinical Trials
1,696,842 Total Patients Enrolled
2 Trials studying Uveitis
118 Patients Enrolled for Uveitis
University of California, DavisOTHER
944 Previous Clinical Trials
4,755,875 Total Patients Enrolled
1 Trials studying Uveitis
118 Patients Enrolled for Uveitis

Media Library

MDS (Comprehensive Sequencing) Clinical Trial Eligibility Overview. Trial Name: NCT05286203 — N/A
Uveitis Research Study Groups: MDS, Standard of Care
Uveitis Clinical Trial 2023: MDS Highlights & Side Effects. Trial Name: NCT05286203 — N/A
MDS (Comprehensive Sequencing) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05286203 — N/A
~45 spots leftby Dec 2026
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