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Behavioural Intervention

Cognitive Rehabilitation for Post-COVID Syndrome

N/A
Recruiting
Led By Anna E Boone, PhD, OTR/L
Research Sponsored by University of Missouri-Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Self-reported cognitive symptoms persisting for at least 6 weeks following COVID-19 infection (Cognitive Failures Questionnaire (CFQ) score >43)
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up pre-intervention (week 0), week 2, week 4, week 6, week 8, and post-intervention (week 12)
Awards & highlights

Study Summary

This trial will assess if a remote therapy called CO-OP can help people with PCS and cognitive impairments with activity performance, cognition, and quality of life.

Who is the study for?
This trial is for individuals who have had COVID-19 and are struggling with cognitive issues at least 6 weeks after infection. Participants should be able to set personal goals, speak English fluently, give informed consent electronically, and have a past diagnosis of COVID-19. People with severe depression, untreated sleep apnea, prior cancer treatment, serious neurological or psychiatric conditions, or signs of dementia are not eligible.Check my eligibility
What is being tested?
The study tests if CO-OP (Cognitive Orientation to daily Occupational Performance) delivered remotely can help improve everyday activity performance, cognition and quality of life in people with Post-COVID Syndrome compared to an inactive control group.See study design
What are the potential side effects?
Since the intervention involves cognitive rehabilitation procedures rather than medication or invasive therapy, significant side effects are not anticipated. However, participants may experience fatigue or frustration during cognitive tasks.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I've had memory or thinking problems for over 6 weeks after COVID-19.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~pre-intervention (week 0), week 2, week 4, week 6, week 8, and post-intervention (week 12)
This trial's timeline: 3 weeks for screening, Varies for treatment, and pre-intervention (week 0), week 2, week 4, week 6, week 8, and post-intervention (week 12) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Acceptability of Intervention Measure (AIM)
Canadian Occupational Performance Measure (COPM)
Feasibility measures
+3 more
Secondary outcome measures
CANTAB Delayed Matching to Sample Subtest
CANTAB Paired Associates Learning Subtest
CANTAB Spatial Working Memory Subtest
+5 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Cognitive Orientation to daily Occupational Performance (CO-OP)Experimental Treatment1 Intervention
Each CO-OP session will last 45 minutes and subjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform.
Group II: Inactive Control GroupActive Control1 Intervention
Subjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
CO-OP Procedures
2022
N/A
~50

Find a Location

Who is running the clinical trial?

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NIH
1,978 Previous Clinical Trials
2,680,288 Total Patients Enrolled
University of Missouri-ColumbiaLead Sponsor
367 Previous Clinical Trials
628,352 Total Patients Enrolled
Anna E Boone, PhD, OTR/LPrincipal InvestigatorUniversity of Missouri Occupational Therapy
2 Previous Clinical Trials
74 Total Patients Enrolled
~43 spots leftby Dec 2025
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