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Slow-wave disruption for Depression (SWIP Trial)

N/A

Waitlist Available

Led By Jennifer Goldschmied, PhD

Research Sponsored by University of Pennsylvania

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age: 25-50

Normal cognition

Must not have

Lifetime history of electroconvulsive therapy

No history of depression for the control group

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to a month

Awards & highlights

No Placebo-Only Group

Summary

This trial will investigate whether a new treatment for depression, which involves manipulating sleep, can help improve mood by increasing synaptic strength.

Who is the study for?

This trial is for adults aged 25-50 with current depression, normal cognition, and stable sleep-wake cycles. Participants must be right-handed, English-speaking, with normal or corrected vision/hearing. Excluded are those with certain mental health histories, implanted devices, recent extensive travel, pregnancy in women, or unwillingness to avoid alcohol/caffeine.

What is being tested?

The study tests whether disrupting slow-wave activity (SWA) during sleep can improve synaptic plasticity and mood in people with major depressive disorder (MDD). It explores the idea that enhancing SWA might counteract deficits in synaptic strength linked to depression.

What are the potential side effects?

While specific side effects are not detailed here, interventions involving SWA disruption may potentially affect sleep patterns and quality. Any changes to brain activity could also influence mood and cognitive functions temporarily.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 25 and 50 years old.

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My thinking and memory skills are normal.

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My vision and hearing are normal, or corrected to be normal.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have never undergone electroconvulsive therapy.

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I have never been diagnosed with depression.

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I have a sleep disorder that is not insomnia.

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I have had a stroke, epilepsy, brain aneurysm clip, or a head injury that caused me to lose consciousness.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to a month

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to a month

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to a month for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Compare indices of net synaptic strength (theta power, transcranial magnetic stimulation evoked potentials) and markers associated with plasticity (BDNF, behavioral measures of learning/memory) in individuals with MDD to healthy controls

Secondary study objectives

Determine if slow-wave disruption alters mood in individuals with MDD

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Subjects with Major Depressive DisorderExperimental Treatment1 Intervention

Subjects who get assigned to this group will undergo a Diagnostic and Statistical Manual for Mental Disorders (SCID) assessment to determine is they meet criteria for MDD.

Group II: ControlActive Control1 Intervention

Subjects who get assigned to this group will undergo a Diagnostic and Statistical Manual for Mental Disorders (SCID) assessment to determine they do not meet criteria for MDD.

0 / 7Eligibility criteria met