Music-based Cognitive Training for Depression

N/A

Recruiting

Led By Sakina Rizvi, PhD,MACP,RP

Research Sponsored by Unity Health Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up from baseline to 8-weeks

Awards & highlights

No Placebo-Only Group

Summary

This trial will test 8 weeks of music-based cognitive training to improve cognitive function in adults with major depressive disorder.

Who is the study for?

This trial is for adults with Major Depressive Disorder (MDD) who've had over 12 psychotherapy sessions, can engage in English-language music-based cognitive training, have stable medication use for more than 4 weeks, and are experiencing suicidal thoughts. It's not suitable for those with active psychosis, severe mood issues needing urgent care, prior recent music therapy or lessons, or hearing problems.

What is being tested?

The study tests an 8-week program of music-based cognitive training designed to improve attention and executive function in adults with MDD. The training uses techniques from Neurologic Music Therapy (NMT) aimed at addressing cognitive deficits that worsen with depression episodes.

What are the potential side effects?

Since the intervention involves non-pharmacological treatment through music-based exercises, no traditional side effects like those seen with medications are expected. However, participants may experience emotional discomfort or fatigue related to engaging in the activities.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ from baseline to 8-weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~from baseline to 8-weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and from baseline to 8-weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in cognitive flexibility and executive control using the Shifting Attention test

Change in inhibition using the Go/No Go Task

Change in selective attention using the Stroop Test

+2 more

Secondary study objectives

Change in suicidal ideation using the Beck Scale for Suicide Ideation (BSSI)

Changes in affect using the Positive and negative affect schedule - short form (PNAS-SF)

Changes in depression symptoms using the Quick Inventory of Depressive Symptomatology - self-report (QIDS-SR).

+2 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Music-based cognitive trainingExperimental Treatment1 Intervention

Music-based cognitive training sessions are derived from two Neurologic Music Therapy techniques: Musical Attention Control Training (MACT) and Musical Executive Function Training (MEFT). MACT exercises will focus on sustained and selective attention to emphasise flexibility and adaptability of the auditory attention system. MEFT exercises will provide opportunity for decision making, problem solving, reasoning, comprehending, organising, initiating, inhibiting, evaluating, analysing, and creating.

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