Deep Brain Stimulation for Neurological and Psychiatric Conditions

N/A

Recruiting

Led By Darin Dougherty, MD

Research Sponsored by Massachusetts General Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Must not have

Psychiatric Patients: Clinical history of bipolar disorder, Current or past psychotic disorder, Gross structural brain damage, Cognitive impairment that would affect a participant's ability to give informed consent, Current substance abuse, or abuse within the past 3 months, Clinical history of severe personality disorder, Imminent risk of suicide or an inability to control suicide attempts, Evidence of dementia or other significant cognitive impairment on neuropsychological evaluation

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 8 hours for each visit

Awards & highlights

No Placebo-Only Group

Summary

This trial will study the effects of electrical stimulation on approach/avoidance conflict in patients with epilepsy or depression/OCD.

Who is the study for?

This trial is for epilepsy patients with depth electrodes and adults with severe Major Depressive Disorder (MDD) or Obsessive-Compulsive Disorder (OCD) who have a deep brain stimulator implanted. Participants must be right-handed, have normal vision and hearing, and not suffer from bipolar disorder, psychosis, brain damage, cognitive impairments affecting consent ability, recent substance abuse, severe personality disorders or dementia.

What is being tested?

The study examines how electrical stimulation from Deep Brain Stimulators affects decision-making related to reward and aversion in patients. It involves performing tasks while undergoing EEG recordings for those with DBS implants for MDD/OCD and continuous recording in epilepsy monitoring unit subjects.

What are the potential side effects?

While the description does not specify side effects of DBS directly linked to this trial's procedures, common side effects of Deep Brain Stimulation can include headache, seizure during implantation procedure, temporary pain at the implant site(s), infection risk at the implant site(s), speech problems and unwanted mood changes.