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Electrical Stimulation

Brain Stimulation for Epilepsy

N/A
Waitlist Available
Led By Barbara C Jobst, MD
Research Sponsored by Barbara Jobst
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
18 years of age or older
Diagnosis of epilepsy
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 days
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing a device that stimulates the brain to see if it improves memory in people with epilepsy.

Who is the study for?
This trial is for adults over 18 with epilepsy who have had an RNS® device implanted for at least 3 months. Participants must be able to consent and complete tasks as judged by the lead researcher.
What is being tested?
The study examines how brain activity linked to good memory functions in people with epilepsy using ECoG data from those with an RNS® device during memory and navigation tasks.
What are the potential side effects?
While not explicitly stated, potential side effects may include discomfort or changes in seizure patterns due to electrical stimulation, as well as typical risks associated with ECoG data collection.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 18 years old or older.
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I have been diagnosed with epilepsy.
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I have an RNS device for my epilepsy.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Proportion of words recalled with and without stimulation.
Secondary study objectives
Changes in the power spectrum of ECoG data with an increase of recalled words.
Proportion of navigation challenges recalled successfully with and without stimulation.
Proportion of words recalled during times of interictal activity.

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: RNS® NeurostimulatorExperimental Treatment1 Intervention
Subjects with pharmaceutically intractable seizures who have been implanted with a RNS® Neurostimulator.

Find a Location

Who is running the clinical trial?

Barbara JobstLead Sponsor
NeuroPaceIndustry Sponsor
10 Previous Clinical Trials
1,473 Total Patients Enrolled
8 Trials studying Epilepsy
1,387 Patients Enrolled for Epilepsy
Barbara C Jobst, MDPrincipal InvestigatorDartmouth-Hitchcock Medical Center
2 Previous Clinical Trials
116 Total Patients Enrolled
2 Trials studying Epilepsy
116 Patients Enrolled for Epilepsy

Media Library

Electrical Stimulation (Electrical Stimulation) Clinical Trial Eligibility Overview. Trial Name: NCT02781129 — N/A
Epilepsy Research Study Groups: RNS® Neurostimulator
Epilepsy Clinical Trial 2023: Electrical Stimulation Highlights & Side Effects. Trial Name: NCT02781129 — N/A
Electrical Stimulation (Electrical Stimulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02781129 — N/A
~3 spots leftby May 2026
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