Focused Ultrasound for Temporal Lobe Epilepsy
Recruiting in Palo Alto (17 mi)
Age: 18 - 65
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: BrainSonix Inc.
No Placebo Group
Trial Summary
What is the purpose of this trial?
We intend to use focused ultrasound to stimulate or suppress brain activity in patients with epilepsy. We hypothesize that focused ultrasound is capable of brain stimulation or suppression visible with functional MRI, and will not cause tissue damage.
Research Team
Eligibility Criteria
This trial is for people with severe epilepsy that hasn't improved after trying at least three antiepileptic drugs. They should be candidates for a specific type of brain surgery and have evidence of dysfunction in one area of the hippocampus. People can't join if they can't consent, cooperate, or have metal in their head, serious heart issues, certain neurological conditions, or are pregnant.Inclusion Criteria
My seizures haven't improved despite trying three different epilepsy medications.
I have epilepsy not controlled by medication and have been recommended a specific brain surgery.
My tests show I have a problem with one side of my brain causing seizures.
See 1 more
Exclusion Criteria
Subjects with dementia, delirium and psychotic symptoms
I am able to understand and agree to the study's requirements.
I am currently pregnant.
See 5 more
Treatment Details
Interventions
- Low-intensity Focused Ultrasound Pulsation (LIFUP) (Ultrasound Therapy)
Trial OverviewThe study tests Low-intensity Focused Ultrasound Pulsation (LIFUP) to see if it can stimulate or suppress brain activity without causing damage. This non-invasive technique's effects will be monitored using functional MRI in patients who could benefit from surgical intervention.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: LIFUPExperimental Treatment1 Intervention
Find a Clinic Near You
Who Is Running the Clinical Trial?
BrainSonix Inc.
Lead Sponsor
Trials
1
Recruited
10+
Gerald J. & Dorothy R. Friedman Center for Lymphedema Research & Treatment
Collaborator
Trials
1
Recruited
10+
University of California, Los Angeles
Collaborator
Trials
1,594
Recruited
10,430,000+
Dr. Thomas Rando
University of California, Los Angeles
Chief Medical Officer since 2023
MD from UCLA
Amir Naiberg
University of California, Los Angeles
Chief Executive Officer since 2024
JD from UCLA