Focused Ultrasound for Temporal Lobe Epilepsy

Palo Alto (17 mi)

Age: 18 - 65

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: N/A

Waitlist Available

Sponsor: BrainSonix Inc.

No Placebo Group

Trial Summary

What is the purpose of this trial?We intend to use focused ultrasound to stimulate or suppress brain activity in patients with epilepsy. We hypothesize that focused ultrasound is capable of brain stimulation or suppression visible with functional MRI, and will not cause tissue damage.

Eligibility Criteria

This trial is for people with severe epilepsy that hasn't improved after trying at least three antiepileptic drugs. They should be candidates for a specific type of brain surgery and have evidence of dysfunction in one area of the hippocampus. People can't join if they can't consent, cooperate, or have metal in their head, serious heart issues, certain neurological conditions, or are pregnant.

Inclusion Criteria

My seizures haven't improved despite trying three different epilepsy medications.

I have epilepsy not controlled by medication and have been recommended a specific brain surgery.

My tests show I have a problem with one side of my brain causing seizures.

Exclusion Criteria

I am able to understand and agree to the study's requirements.

I am currently pregnant.

I do not have severe heart issues, high brain pressure, or use a TENS unit.

I experience widespread seizures or non-epileptic seizures.

My seizures are caused by drugs, alcohol, a metabolic illness, or a progressive disease.

Treatment Details

The study tests Low-intensity Focused Ultrasound Pulsation (LIFUP) to see if it can stimulate or suppress brain activity without causing damage. This non-invasive technique's effects will be monitored using functional MRI in patients who could benefit from surgical intervention.

1Treatment groups

Experimental Treatment

Group I: LIFUPExperimental Treatment1 Intervention