Tyrosol + Creatine for Endurance and Strength
Recruiting in Palo Alto (17 mi)
Overseen byEric Sikorski, PhD
Age: 18 - 65
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Applied Science & Performance Institute
Trial Summary
What is the purpose of this trial?The purpose of this clinical trial is to look at tyrosol's effects on endurance, strength, and fatigue resistance in humans. Additionally, the combination of tyrosol and creatine monohydrate will also be looked at to determine if there is a cooperative effect from using both together. It will be conducted over a 4-week period to compare the effects of the following substances: 1) tyrosol, 2) a placebo (a look-alike substance that contains no drug), 3) creatine, and 4) a combination containing both creatine and tyrosol. Endurance, strength, and fatigue resistance will be compared between groups through repeated testing (described below).
Participants who pass initial screening will be invited on-site for day one (Visit 1) of testing where they will proceed with a series of tests which will include the following: (1) body composition; (2) cognitive testing; (3) full-body strength testing; (4) grip strength on both hands; (5) muscle power testing; (6 \& 7) Resting blood lactic acid testing followed by 5RM (repetition maximum) bench press, leading to multiple sets of bench press (based on the previous weight) completed to failure, followed by another blood lactic acid reading; (8) a repeat of the muscle power testing; (9) a 1 mile time trial run completed as fast as possible.
After the 4-week supplementation period (\~28-34 days), all original measures will be repeated as before in the same order (Visit 2). Approximately 24 hours later (Visit 3) participants will then repeat all physical testing procedures except tests 1, 6, 7, and 8, to determine physical recovery. Additionally, questionnaires for soreness and perceived recovery will also be completed at the beginning of Visit 2 and 3, and again on its own as the only testing event at 48 hours post-Visit 2 (visit 4).
Eligibility Criteria
Healthy adults aged 18-50 who are moderately active at least twice a week, with good cardiovascular fitness (VO2 max in the top 50% for their age). They must not have had recent injuries or surgeries, be non-smokers and light drinkers, and avoid other supplements that affect muscle strength or endurance during the study. Women must share menstrual cycle information.Inclusion Criteria
Currently active (engaged in moderate to vigorous activity at least 2-days per week as defined by the American College of Sports Medicine Guidelines)
Able to read and write in English
My fitness level is at or above average for my age.
+3 more
Exclusion Criteria
Regular smoker
Regular drinker (>14 drinks per week)
Current use of dietary supplements that may enhance mitochondrial function, muscle hypertrophy, or muscle strength (e.g. protein formulas, creatine, amino acids, tyrosol, etc.)
+9 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
1 visit (in-person)
Baseline Testing
Participants undergo a series of baseline tests including body composition, cognitive testing, strength testing, and endurance testing
1 day
1 visit (in-person)
Treatment
Participants receive daily supplementation of tyrosol, creatine, or placebo for 4 weeks
4 weeks
Daily administration (self-administered)
Post-Treatment Testing
All baseline measures are repeated to assess the effects of the supplementation
2 days
2 visits (in-person)
Follow-up
Participants are monitored for recovery and any adverse events post-treatment
1 week
1 visit (in-person)
Participant Groups
The trial is testing how tyrosol affects endurance, strength, and fatigue resistance alone and when combined with creatine over four weeks. Participants will undergo tests including body composition, cognitive function, full-body strength, grip strength, muscle power testing, blood lactic acid levels before and after exercise trials.
4Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Tyrosol and CreatineExperimental Treatment2 Interventions
creatine and tyrosol (3g creatine monohydrate + 500mg tyrosol/day) administered daily
Group II: Tyrosol + placeboExperimental Treatment2 Interventions
500mg Tyrosol (administered daily as 1 capsule, containing 500mg/capsule) + 3g of resistant dextrin powder (placebo)
Group III: Creatine + placeboActive Control2 Interventions
3g Creatine Monohydrate powder + 500mg Resistant dextrin capsules (as 1 capsule, containing 500mg/capsule) (placebo) administered daily
Group IV: placebo + placeboPlacebo Group1 Intervention
3g of resistant dextrin powder (placebo) + 500mg Resistant dextrin capsules (administered as 1 capsule, containing 500mg/capsule) (placebo) administered daily
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Applied Science & Performance InstituteTampa, FL
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Who Is Running the Clinical Trial?
Applied Science & Performance InstituteLead Sponsor