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Molecular Imaging

Molecular Imaging with MRI for Brain Cancer

N/A

Recruiting

Led By Macarena De La Fuente, MD

Research Sponsored by University of Miami

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Adults (≥18 year old)

Be older than 18 years old

Must not have

Adults unable to consent

Individuals who are not yet adults (infants, children, teenagers)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up day 1

Awards & highlights

No Placebo-Only Group

Summary

This trial shows that MRI can be used to measure 2HG in gliomas, which could help guide the development of new therapies for this type of cancer.

Who is the study for?

This trial is for adults over 18 with suspected or confirmed gliomas who are scheduled for a medically indicated brain biopsy or resection. It's not suitable for those unable to consent, minors, pregnant women, or patients who can't undergo MRI scans.

What is being tested?

The study uses a high-tech MRI scanner to non-invasively measure the distribution of a specific molecule (2HG) and cell density in brain tumors. This could help in developing new treatments for gliomas.

What are the potential side effects?

Since this trial involves only MRI scanning, there are no direct side effects like you'd expect from drugs or surgery. However, some people might experience discomfort from lying still during the scan.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am 18 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I am unable to give consent for myself.

Select...

I am under the age of 18.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ day 1

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~day 1

This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

2HG Concentration from tissue samples

2HG Concentration via 3T MRI Scanner

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: IDH-Mutant Glioma PatientsExperimental Treatment1 Intervention

Patients who have suspected or confirmed gliomas and are scheduled to undergo biopsy or resection of their brain tumors will receive a 3 Tesla (3T) Magnetic Resonance Imaging (MRI) scan of their brain.

0 / 3Eligibility criteria met