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Dietary Supplement

Diet and Oxalate Absorption for Kidney Stones

N/A
Recruiting
Led By Sonia Fargue, PhD
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 day
Awards & highlights
No Placebo-Only Group

Summary

This trial aims to see if people with a history of calcium oxalate kidney stones absorb more oxalate from their diet, leading to higher levels of oxalate in their urine. They will

Who is the study for?
This trial is for adults who've had calcium oxalate kidney stones and healthy volunteers without a history of these stones. Participants will follow specific diets and undergo tests to study how their bodies handle oxalate.
What is being tested?
The trial involves participants eating low and high-oxalate diets for five days each, taking an oxalate absorption test with sugar solutions, and providing urine, blood, stool, and breath samples to measure the effects.
What are the potential side effects?
There may be minimal side effects from the dietary changes or discomfort from sample collection. The soluble oxalate test might cause mild gastrointestinal upset in some individuals.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 day
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 day for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Net Gastrointestinal absorption of food-bound oxalate
Secondary study objectives
Absorption of soluble 13C2-oxalate
Estimated endogenous oxalate synthesis (oxalate mg/day)

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Idiopathic Calcium Oxalate Kidney Stone PatientsExperimental Treatment3 Interventions
Low and High oxalate fixed diets. Soluble oxalate absorption test.
Group II: Healthy non-kidney stone forming individualsActive Control3 Interventions
Low and High oxalate fixed diets. Soluble oxalate absorption test.

Find a Location

Who is running the clinical trial?

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,463 Previous Clinical Trials
4,337,323 Total Patients Enrolled
University of Alabama at BirminghamLead Sponsor
1,655 Previous Clinical Trials
2,444,078 Total Patients Enrolled
University of Texas Southwestern Medical CenterOTHER
1,088 Previous Clinical Trials
1,059,630 Total Patients Enrolled
Sonia Fargue, PhDPrincipal InvestigatorUniversity of Alabama at Birmingham
2 Previous Clinical Trials
100 Total Patients Enrolled
~53 spots leftby Dec 2030
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