Curcumin, Omega-3, and Vitamin D Supplements for Healthy Subjects
(PASCOD3 Trial)

Recruiting in Palo Alto (17 mi)

+1 other location

Overseen byLiam O'Neil, MD, MHSc

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Manitoba

No Placebo Group

Trial Summary

What is the purpose of this trial?The goal of this clinical trial is to determine if the level of Anti-cyclic citrullinated peptide antibody (ACPA) is altered after taking curcumin, omega-3, and vitamin D supplements (COD) for 3 months. It will also determine the safety and tolerability of COD in the study population. This trial aims to answer the following questions: Does COD consumption lower the level of ACPA in the study participants? What side effects will participants have after taking COD? This pilot study will have an open label pre-post design and study participants will know that they are using each of the three supplements. Participants will: Take the combination of supplements following an evening meal, for 84 consecutive days. Visit the clinic/study team twice during the study duration on days 0 and 84 for checkups and tests. Keep a diary of study treatment consumption.

Eligibility Criteria

This trial is for healthy individuals who have a specific antibody called ACPA in their blood. Participants will be taking a combination of supplements—curcumin, omega-3, and vitamin D—for three months to see if it affects the levels of ACPA.

Inclusion Criteria

I am willing to stop taking my vitamin D and omega-3 supplements for this trial.

I am willing to use effective birth control during the trial.

Participant has clinically acceptable laboratory results including routine hematology (CBC) and biochemistry (electrolytes, creatinine, ALT, ALP, GGT, AST, Glucose)

+5 more

Exclusion Criteria

I have surgery planned that will need general anesthesia during the trial.

Current consumption of > 14 drinks per week, (1 drink = 12oz of beer, 5oz of wine or 1.5oz distilled spirits)

I have lost or gained more than 3.5 kg in the last 3 months without a known reason.

+11 more

Participant Groups

The study tests whether consuming curcumin, omega-3, and vitamin D (COD) can lower Anti-cyclic citrullinated peptide antibody (ACPA) levels. It's an open-label pre-post design where participants know they're taking the supplements and must follow up with the clinic on days 0 and 84.

1Treatment groups

Experimental Treatment

Group I: curcumin, omega-3, and vitamin D (COD)Experimental Treatment1 Intervention

Acumin™Turmeric Complex/Dr. D's Ultra BioTurmeric: 500 mg/day (oral, 2 tablets taken by mouth), Vitamin D: 2500 IU/day (oral, 1 tablet taken by mouth), Omega-3: 900 mg day (oral, 1 tablet taken by mouth)