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Exercise Training for Heart Failure

N/A
Recruiting
Research Sponsored by University of Texas Southwestern Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Signs and symptoms of heart failure
signs and symptoms of heart failure
Must not have
CKD 4 or higher
Age < 60 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 months
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing whether different types of exercise training programs can improve exercise tolerance for people with heart failure and preserved ejection fraction.

Who is the study for?
This trial is for people over 60 with heart failure who still have a decent amount of blood pumped from their heart each beat (ejection fraction > 0.50) and signs of poor relaxation of the heart muscle. They shouldn't be extremely overweight, taking certain drugs for erectile dysfunction, have severe valve disease or lung problems, very poor kidney function, or an inability to undergo MRI scans.
What is being tested?
The study aims to understand why patients with HFpEF get tired easily during exercise and feel shortness of breath. It will test if specific types of exercise programs can help improve their ability to exercise without getting as tired or breathless.
What are the potential side effects?
Since this trial involves exercise training programs, potential side effects may include muscle soreness, fatigue, joint pain or discomfort during physical activity. The risks are generally low but depend on individual health status.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am experiencing signs of heart failure.
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I show signs or symptoms of heart failure.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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My kidney function is severely reduced.
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I am younger than 60 years old.
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I have a serious heart valve problem.
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I am currently taking medication for erectile dysfunction.
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I have severe chronic obstructive pulmonary disease.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Aerobic fitness
Secondary study objectives
Cardiac fibrosis
Cardiopulmonary hemodynamics
Leg blood flow
+1 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups
Experimental Treatment
Group I: Peripheral HFpEF whole body exerciseExperimental Treatment1 Intervention
HFpEF patients who have a peripheral limitation as the cause of the exercise intolerance randomized to whole body cycle training.
Group II: Peripheral HFpEF isolated single leg exerciseExperimental Treatment1 Intervention
HFpEF patients who have a peripheral limitation as the cause of the exercise intolerance randomized to isolated single leg training.
Group III: Central HFpEF whole body exerciseExperimental Treatment1 Intervention
HFpEF patients who have a central limitation as the cause of the exercise intolerance randomized to whole body cycle training.
Group IV: Central HFpEF isolated single leg exerciseExperimental Treatment1 Intervention
HFpEF patients who have a central limitation as the cause of the exercise intolerance randomized to isolated single leg training.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Exercise training
2019
Completed Phase 1
~1110

Find a Location

Who is running the clinical trial?

The University of Texas at ArlingtonOTHER
45 Previous Clinical Trials
4,808 Total Patients Enrolled
1 Trials studying Heart Failure
12 Patients Enrolled for Heart Failure
University of Texas-ArlingtonUNKNOWN
4 Previous Clinical Trials
650 Total Patients Enrolled
University of Texas Southwestern Medical CenterLead Sponsor
1,089 Previous Clinical Trials
1,059,604 Total Patients Enrolled
26 Trials studying Heart Failure
13,652 Patients Enrolled for Heart Failure

Media Library

Exercise training Clinical Trial Eligibility Overview. Trial Name: NCT04068844 — N/A
Heart Failure Research Study Groups: Peripheral HFpEF isolated single leg exercise, Central HFpEF isolated single leg exercise, Central HFpEF whole body exercise, Peripheral HFpEF whole body exercise
Heart Failure Clinical Trial 2023: Exercise training Highlights & Side Effects. Trial Name: NCT04068844 — N/A
Exercise training 2023 Treatment Timeline for Medical Study. Trial Name: NCT04068844 — N/A
~8 spots leftby Jul 2025
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