MRI for Heart Failure
Trial Summary
What is the purpose of this trial?
Patients with heart failure (HF) exhibit greater structural brain alterations and higher dementia risks than the general population. Neural atrophy in nearly every region of medical limbic circuit has been observed in HF patients. Reduction of cerebral blood flow has been suggested as the pathophysiological pathway linking HF and structural brain changes. Indeed, lower cardiac index levels were related to lower cerebral blood flow in older adults without stroke, dementia, or heart failure. A few prior studies have examined the subcortical structural differences in patients with HF compared to controls. Brain volume loss (including putamen and hippocampal volumes) have been reported in patients with low ejection fraction. Significant gray matter loss was found in specific brain regions of HF patients and included structures that serve demonstrated roles in cognitive functions. In the investigator's previous study (Comprehensive Imaging Exam of Convalesced COVID-19 Patients - COVID-19 RELATED SUBMISSION-IRB00252436), involving 100 participants (volunteers with normal heart function (ejection fraction; 50%)), the investigators observed significant correlations between thalamic volumes and ventricular stroke volumes in volunteers. Building on these findings, the investigators intend to expand the research to include individuals with heart failure (HF), employing the same MRI protocol. The study will involve obtaining a set of T1-weighted brain images to measure the volumes of seven subcortical structures. The investigators goal is to explore the relationship between subcortical volumes and cardiac parameters. Additionally, the investigators will examine whether patients with HF experience a more rapid reduction in subcortical volumes compared to those with normal cardiac function (EF;50%).
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of MRI as a treatment for heart failure?
Is MRI safe for heart failure patients?
MRI, when using gadolinium-based contrast agents, has been studied for safety in heart imaging. Research shows that these agents are generally safe, with some risk of mild adverse reactions. It's important to discuss any concerns with your doctor, especially if you have kidney issues, as they can affect how your body handles these agents.678910
How does MRI differ from other treatments for heart failure?
MRI for heart failure is unique because it is a non-invasive imaging technique that provides detailed pictures of the heart's structure and function, unlike traditional treatments that may involve medication or surgery. It can be particularly useful for patients with complex heart conditions or those who cannot undergo other imaging methods due to body size or metal implants.111121314
Research Team
Joao AC Lima, MD
Principal Investigator
Johns Hopkins University
Eligibility Criteria
This trial is for adults over 21 who can walk on their own and have heart failure with an ejection fraction below 50%. They must not be claustrophobic to undergo MRI scans. Participants need to give informed consent.Inclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Imaging Assessment
Participants undergo MRI to measure subcortical brain volumes and assess cardiac parameters
Follow-up
Participants are monitored for changes in subcortical volumes and cardiac function
Treatment Details
Interventions
- Magnetic Resonance Imaging (Procedure)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Johns Hopkins University
Lead Sponsor
Canon Medical Systems, USA
Industry Sponsor