Trial Summary
What is the purpose of this trial?The objective is to determine the effectiveness of pulsatile flow during cardiopulmonary bypass to reduce the incidence of acute kidney injury after cardiac surgery. Investigators will also evaluate the safety and impact of pulsatile flow on clinical outcomes compared to non-pulsatile flow during cardiopulmonary bypass.
Eligibility Criteria
This trial is for patients undergoing cardiac surgery who will be on cardiopulmonary bypass. It's not clear what specific conditions or characteristics make someone eligible or ineligible to participate.Inclusion Criteria
Able to provide informed consent
I am scheduled for heart surgery that will use a heart-lung machine.
Exclusion Criteria
Emergency procedures
Scheduled for ventricular assist device implantation
I need medication to control my blood pressure.
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Participant Groups
The study is testing if pulsatile blood flow (mimicking natural heartbeat rhythms) during cardiopulmonary bypass can reduce kidney damage after heart surgery, compared to non-pulsatile flow (steady stream).
2Treatment groups
Active Control
Group I: Pulsatile blood flowActive Control1 Intervention
Pulsatile blood flow during cardiopulmonary bypass
Group II: Non-pulsatile blood flowActive Control1 Intervention
Non-pulsatile blood flow during cardiopulmonary bypass
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
University of Colorado HospitalAurora, CO
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Who Is Running the Clinical Trial?
University of Colorado, DenverLead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)Collaborator