Low-Oxalate Diet for Kidney Stones
Trial Summary
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study coordinators or your doctor.
Research suggests that a low-oxalate diet can reduce the amount of oxalate in urine, which is linked to kidney stone formation. For example, a study showed that patients on a low-oxalate, low-fat diet had decreased urinary oxalate levels, which can help prevent kidney stones.
12345A low-oxalate diet has been studied in patients with high oxalate levels in their urine, and it was found to be manageable with proper dietary guidance, though it can be demanding. No specific safety concerns were reported in the studies, suggesting it is generally safe for humans.
25678The low-oxalate diet treatment for kidney stones is unique because it focuses on reducing oxalate intake, which can help lower urinary oxalate levels and potentially prevent stone formation. Unlike other treatments that may involve medication or surgery, this approach is dietary and requires careful management of food choices, often with guidance from a dietitian.
1291011Eligibility Criteria
This trial is for adults aged 18-70 who have had bariatric surgery or are obese, with a history of calcium-based kidney stones and high urine oxalate levels. It's not for those with certain bowel surgeries, inflammatory bowel disease, or non-calcium based kidney stones.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Diet Preparation
Participants follow a special low-oxalate diet at home for the first two days
Controlled Diet and Sample Collection
Participants receive special meals from the research clinic and collect 24-hour urine samples at home
Clinic Visit and Testing
Participants visit the research clinic for administration of a special liquid containing oxalate and a low-oxalate breakfast
Follow-up
Participants are monitored for changes in urine oxalate and sucralose levels after the intervention
Participant Groups
Special low-oxalate diet followed by all-day visit to University of Chicago research clinic is already approved in United States for the following indications:
- Prevention of Kidney Stones
- Management of Hyperoxaluria