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Control group for Post-Traumatic Stress Disorder (CANPOST Trial)

N/A
Recruiting
Research Sponsored by Centre for Addiction and Mental Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 0-4
Awards & highlights

CANPOST Trial Summary

This trial will compare two different therapies for people with PTSD and cannabis-use disorder. One group will receive motivational interviewing therapy and contingency management, while the other group will just receive motivational interviewing therapy.

Who is the study for?
This trial is for English-speaking adults aged 18-55 with PTSD and moderate to severe cannabis use disorder, who have been on antidepressants for at least a month. It's not open to those with severe medical conditions, schizophrenia, bipolar disorder, acute psychosis or mania, high suicide risk, or pain that interferes with normal function.Check my eligibility
What is being tested?
The study compares two approaches over 12 weeks: one group receives motivational interviewing plus contingency management (rewards for meeting goals), while the control group gets only motivational interviewing. Both groups consist of outpatients from CAMH.See study design
What are the potential side effects?
While specific side effects are not listed here, common concerns in such trials may include emotional distress due to therapy discussions and potential withdrawal symptoms from reduced cannabis use.

CANPOST Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 0-4
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 0-4 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Severity of PTSD symptoms, as measured with the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) at week 4
Secondary outcome measures
Changes in cognitive function, as measured with various Cambridge Automated Neuropsychological Test Automated Battery (CANTAB) cognitive tests

CANPOST Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Control groupExperimental Treatment1 Intervention
Randomized to receive individual motivational interviewing therapy alone
Group II: Contingency management groupActive Control2 Interventions
Randomized to receive individual motivational interviewing therapy and contingency management

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Who is running the clinical trial?

Centre for Addiction and Mental HealthLead Sponsor
358 Previous Clinical Trials
81,231 Total Patients Enrolled
~2 spots leftby Sep 2024
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