Popular Trials
Procedure
NUV-868 + Olaparib/Enzalutamide for Cancer
This trial tests a new drug, NUV-868, taken regularly by mouth, in patients with advanced cancers. It aims to find the best dose and see if combining it with other drugs can improve treatment. The study includes patients with advanced solid tumors and a specific type of prostate cancer.
Angiogenesis Inhibitor
Cediranib + Olaparib for Ovarian and Breast Cancer
This trial is testing the combination of two drugs, cediranib maleate and olaparib, to treat patients with certain types of recurrent cancer. Cediranib maleate cuts off the blood supply to cancer cells, while olaparib stops them from repairing their DNA. The trial aims to find the best dose and see if the combination works better than using olaparib by itself. Combining cediranib, which cuts off the blood supply to cancer cells, with olaparib, which stops cancer cells from repairing their DNA, may help patients live longer without their cancer getting worse.
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Trials for Breast Cancer Patients
Monoclonal Antibodies
SGN-B7H4V for Advanced Cancers
This trial tests a new drug called SGN-B7H4V for safety and side effects in patients with advanced or metastatic solid tumors. It aims to find the right dosage and see if the drug can effectively treat their cancer.
Monoclonal Antibodies
MK-7684A for Advanced Cancers
This trial is testing a new treatment that combines two medications to see if it works better than the current treatment for serious cancers, particularly cervical cancer. One of the medications has shown promising results in treating various cancers, including cervical cancer. The goal is to find out if this combination can improve patient outcomes by helping the immune system fight cancer more effectively.
Immunotherapy
BMS-986340 + Nivolumab/Docetaxel for Cancer
This trial tests a new drug, BMS-986340, alone and with other cancer treatments (nivolumab and docetaxel) in patients with advanced solid tumors. The goal is to find out if it is safe and effective in treating these cancers.
PARP Inhibitor
Olaparib + Pembrolizumab for Breast Cancer
This trial is comparing the efficacy of two different treatments for triple negative breast cancer - olaparib plus pembrolizumab versus chemotherapy plus pembrolizumab. The primary hypotheses are that olaparib plus pembrolizumab will be superior to chemotherapy plus pembrolizumab in terms of progression-free survival and overall survival.
Trials for LABC Patients
Monoclonal Antibodies
SGN-B7H4V for Advanced Cancers
This trial tests a new drug called SGN-B7H4V for safety and side effects in patients with advanced or metastatic solid tumors. It aims to find the right dosage and see if the drug can effectively treat their cancer.
Monoclonal Antibodies
MK-7684A for Advanced Cancers
This trial is testing a new treatment that combines two medications to see if it works better than the current treatment for serious cancers, particularly cervical cancer. One of the medications has shown promising results in treating various cancers, including cervical cancer. The goal is to find out if this combination can improve patient outcomes by helping the immune system fight cancer more effectively.
Immunotherapy
BMS-986340 + Nivolumab/Docetaxel for Cancer
This trial tests a new drug, BMS-986340, alone and with other cancer treatments (nivolumab and docetaxel) in patients with advanced solid tumors. The goal is to find out if it is safe and effective in treating these cancers.
PARP Inhibitor
Olaparib + Pembrolizumab for Breast Cancer
This trial is comparing the efficacy of two different treatments for triple negative breast cancer - olaparib plus pembrolizumab versus chemotherapy plus pembrolizumab. The primary hypotheses are that olaparib plus pembrolizumab will be superior to chemotherapy plus pembrolizumab in terms of progression-free survival and overall survival.
Trials for Metastatic Patients
Monoclonal Antibodies
SGN-B7H4V for Advanced Cancers
This trial tests a new drug called SGN-B7H4V for safety and side effects in patients with advanced or metastatic solid tumors. It aims to find the right dosage and see if the drug can effectively treat their cancer.
Monoclonal Antibodies
MK-7684A for Advanced Cancers
This trial is testing a new treatment that combines two medications to see if it works better than the current treatment for serious cancers, particularly cervical cancer. One of the medications has shown promising results in treating various cancers, including cervical cancer. The goal is to find out if this combination can improve patient outcomes by helping the immune system fight cancer more effectively.
Immunotherapy
BMS-986340 + Nivolumab/Docetaxel for Cancer
This trial tests a new drug, BMS-986340, alone and with other cancer treatments (nivolumab and docetaxel) in patients with advanced solid tumors. The goal is to find out if it is safe and effective in treating these cancers.
PARP Inhibitor
Olaparib + Pembrolizumab for Breast Cancer
This trial is comparing the efficacy of two different treatments for triple negative breast cancer - olaparib plus pembrolizumab versus chemotherapy plus pembrolizumab. The primary hypotheses are that olaparib plus pembrolizumab will be superior to chemotherapy plus pembrolizumab in terms of progression-free survival and overall survival.
Trials for ER Positive Patients
Monoclonal Antibodies
Pembrolizumab + Mifepristone for Breast Cancer
This trial is testing a combination of two drugs to treat advanced breast cancer. The first part of the trial will test the safety of the combination in ten patients. If the combination is safe, the trial will expand to include more patients.
Chemotherapy
Personalized Adaptive Novel Agents for Breast Cancer
This trial is testing new medicines along with regular cancer treatment to find the best combinations for breast cancer patients. It focuses on identifying which treatments work best based on specific cancer characteristics. Early signs of success are monitored using MRI scans and tests on blood and tissue samples.
DHODH Inhibitor
Leflunomide for Triple Negative Breast Cancer
This trial is testing the safety and effectiveness of leflunomide, a daily oral medication, in women with aggressive triple negative breast cancer. The drug aims to block a substance that helps cancer cells grow. The study focuses on women who have already tried other treatments.
Monoclonal Antibodies
DS-1062a for Non-Small Cell Lung Cancer
This trial tests a new drug, DS-1062a, on patients with advanced cancers who haven't been cured by other treatments. The goal is to find the safest dose and see if the drug can help treat these cancers.
Trials for PD-L1 Positive Patients
Chemotherapy
KFA115 + Tislelizumab for Advanced Cancers
This trial tests a new drug, KFA115, alone and with pembrolizumab in patients with advanced cancers. It aims to find the safest dose and see if the drugs can reduce tumors. The focus is on patients whose cancers are hard to treat with current options.
PD-L1 Inhibitor
SGN-PDL1V for Cancer
This trial is testing a new drug, SGN-PDL1V, alone and with pembrolizumab, in patients with advanced solid tumors. The goal is to see if these treatments are safe and effective. SGN-PDL1V targets cancer cells directly, while pembrolizumab helps the immune system fight the cancer.
Monoclonal Antibodies
Combination Therapies for Breast Cancer
This trial is testing multiple immunotherapy-based treatment combinations to see if they are effective and safe in patients with metastatic or inoperable TNBC. The study will be performed in two stages, with different cohorts of patients in each stage.
Phase 3 Trials
Monoclonal Antibodies
Chemotherapy + Atezolizumab for Breast Cancer
This trial is studying whether a combination of the standard chemotherapy regimen for breast cancer plus the experimental drug atezolizumab is more effective than the standard chemotherapy regimen plus a placebo.
Cancer Vaccine
Adagloxad Simolenin + OBI-821 for Triple Negative Breast Cancer
This trial is testing a new treatment that combines two substances to help the immune system fight a specific type of high-risk breast cancer. It focuses on patients whose cancer does not respond well to usual treatments.
PARP Inhibitor
Niraparib for Breast Cancer
This trial is testing Niraparib, a drug that stops cancer cells from fixing their broken DNA, in patients with certain types of breast cancer that are either genetically aggressive or have signs of remaining disease after treatment. Niraparib is a drug already used for ovarian cancer and has shown promise in treating breast cancer with certain genetic markers.
Anti-mitotic Agent
Nanosomal Docetaxel for Triple Negative Breast Cancer
This trial tests a new, safer form of the cancer drug docetaxel, called Nanosomal Docetaxel Lipid Suspension (NDLS), in patients with advanced or spreading triple-negative breast cancer. NDLS aims to reduce side effects by using tiny fat particles. The drug works by stopping cancer cells from dividing and growing. Docetaxel is a widely used chemotherapy drug, and newer formulations like Nanosomal Docetaxel Lipid Suspension (NDLS) aim to improve its efficacy and reduce toxicity.
Trials With No Placebo
Monoclonal Antibodies
SGN-B7H4V for Advanced Cancers
This trial tests a new drug called SGN-B7H4V for safety and side effects in patients with advanced or metastatic solid tumors. It aims to find the right dosage and see if the drug can effectively treat their cancer.
Monoclonal Antibodies
MK-7684A for Advanced Cancers
This trial is testing a new treatment that combines two medications to see if it works better than the current treatment for serious cancers, particularly cervical cancer. One of the medications has shown promising results in treating various cancers, including cervical cancer. The goal is to find out if this combination can improve patient outcomes by helping the immune system fight cancer more effectively.
Immunotherapy
BMS-986340 + Nivolumab/Docetaxel for Cancer
This trial tests a new drug, BMS-986340, alone and with other cancer treatments (nivolumab and docetaxel) in patients with advanced solid tumors. The goal is to find out if it is safe and effective in treating these cancers.
PARP Inhibitor
Olaparib + Pembrolizumab for Breast Cancer
This trial is comparing the efficacy of two different treatments for triple negative breast cancer - olaparib plus pembrolizumab versus chemotherapy plus pembrolizumab. The primary hypotheses are that olaparib plus pembrolizumab will be superior to chemotherapy plus pembrolizumab in terms of progression-free survival and overall survival.
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Frequently Asked Questions
Introduction to triple negative breast cancer
What are the top hospitals conducting triple negative breast cancer research?
When it comes to clinical trials dedicated to tackling the formidable challenge of triple negative breast cancer, several hospitals have emerged as leaders in this field. In Boston, Massachusetts General Hospital is at the forefront with nine active trials focused on triple negative breast cancer and a total of 34 completed studies in this area. Their commitment dates back to 2011 when they initiated their first recorded trial for this specific type of breast cancer. Not far behind, the Dana-Farber Cancer Institute also located in Boston, is making significant strides with eight ongoing clinical trials and an impressive history of 33 previous trials since their inaugural study in 2010 that addressed triple negative breast cancer.
Meanwhile, Memorial Sloan Kettering Cancer Center situated in New york City has established itself as another prominent institution actively engaged in combating triple negative breast cancer. With seven ongoing trials and a remarkable record of 38 completed studies over time since their initial investigation began in 2011 specifically targeting this aggressive form of breast cancer; here too great dedication can be seen towards finding new treatments.
Further down south, MD Anderson Cancer Center based out Houston plays its part by conducting six current clinical tests while having accumulated notable expertise through fourteen previous experiments after launching its first recorded trial centered around triple-negative tumors just a decade ago from now- i.e.,inthe year2012.And finally highlighting Beth Israel Deaconess Medical Center which stands alongside MD Anderson by also contributing six ongoing investigations into developing breakthroughs againsttriple-negativebreastcancer.NotwithstandingbeingrelativelynewerinthefieldtheyalongsidehaveachievedeighteencompletedclinicalstudieswhichstartedwaybacktowardsthoseearlyyearsfromtheirfirsttrialinitiatedinthesimilarlyyearasDanaFarbersonei.e.,during theyearof2010.
With these esteemed institutions leading the charge against triple negative breast cancer through cutting-edge research and innovative clinical trials,tremendoushopeandpotentialforadvancementarebroughttothe table. The collaborative efforts of these top hospitals demonstrate a unified commitment to finding treatments and improving outcomes for those affected by this challenging form of breast cancer.
Which are the best cities for triple negative breast cancer clinical trials?
When it comes to clinical trials for triple negative breast cancer, several cities emerge as top contenders. Boston, Massachusetts leads the pack with 44 active trials investigating Pembrolizumab, Atezolizumab, Cediranib Maleate, and other promising treatments. Houston, Texas closely follows with 40 ongoing studies centered around Pembrolizumab and innovative approaches for tumors larger than 5 cm. New York City also boasts 40 active trials focusing on BMS-986340, Pembrolizumab, Carboplatin, and other potential breakthroughs. Nashville, Tennessee and Chicago, Illinois round out the list with their respective contributions of 33 and 27 active trials exploring Enzalutamide, DF6002,TAK-676,and more. These cities offer hope to individuals battling triple negative breast cancer through cutting-edge research that may lead to improved treatment options in the future.
Which are the top treatments for triple negative breast cancer being explored in clinical trials?
In the realm of clinical trials, several treatments are currently under exploration for triple negative breast cancer. Taking the lead is pembrolizumab, impressively involved in 17 active trials and boasting a total of 82 all-time studies dedicated to this aggressive subtype since its introduction in 2015. Atezolizumab follows closely behind with four ongoing trials and a history of 27 all-time triple negative breast cancer studies since its debut in 2015. Additionally, enzalutamide has shown promise, participating in two active trials and totaling five all-time triple negative breast cancer trials since being listed in 2013. On the horizon are newer contenders NUV-868 and SGN-B7H4V, each making their mark with one active trial and one all-time trial respectively after being introduced just last year (2022). As research progresses tirelessly, these potential breakthroughs offer hope for improved treatment options against this challenging form of breast cancer.
What are the most recent clinical trials for triple negative breast cancer?
Recent clinical trials have brought forth promising advancements in the field of triple negative breast cancer, offering new possibilities for treatment. One notable study focuses on tumors larger than 5 cm and aims to enhance therapeutic outcomes in this specific subgroup. Another trial explores the potential benefits of an Anti-HER2/HER3 Dendritic Cell Vaccine, which holds promise as a targeted approach against triple negative breast cancer. Additionally, researchers are investigating the efficacy and safety profile of SGN-PDL1V and NUV-868 for this aggressive form of breast cancer. These trials mark significant progress in our understanding and management of triple negative breast cancer, providing hope for improved patient outcomes in the future.
What triple negative breast cancer clinical trials were recently completed?
Recent clinical trials have made significant progress in the search for effective treatments for triple negative breast cancer. G1 Therapeutics, Inc.'s trial on Trilaciclib was completed in November 2021, showing promising results. In October 2020, VelosBio Inc. concluded their study on Zilovertamab vedotin, which holds potential as a treatment option. Another notable trial was conducted by Hoffmann-La Roche and focused on Tiragolumab; it reached completion in September 2020. These advancements bring hope to those affected by triple negative breast cancer and highlight the ongoing commitment of researchers to find new breakthroughs that could improve patient outcomes.