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Non-nutritive Sweetener

Non-nutritive Sweeteners for Metabolic Syndrome

N/A
Waitlist Available
Led By Marie-Claude Vohl
Research Sponsored by Laval University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Must not have
Regular use of medication affecting study parameters
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

This trial will test the effects of two types of non-nutritive sweeteners, stevia and aspartame, on metabolic health and the gut microbiome.

Who is the study for?
This trial is for men and women who are generally healthy and regularly consume soft drinks, ranging from 4 cans a week up to 4 cans a day. It's not suitable for those with recent surgeries, allergies to drink ingredients, recent antibiotic use, heavy alcohol consumption, or changes in medication or weight.
What is being tested?
The study tests the effects of daily consumption of three types of beverages over 10 weeks: regular sugary soft drinks, diet soft drinks with artificial sweeteners like aspartame, and stevia-sweetened soft drinks on metabolic health and gut microbiome.
What are the potential side effects?
Potential side effects may include changes in metabolism or gut health due to the different sweeteners used. These could affect blood sugar levels, digestion processes or cause other metabolic disturbances.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I regularly take medication that could affect the study.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Stevia beveragesExperimental Treatment1 Intervention
Soft drinks sweetened with natural non-nutritive sweeteners (i.e. steviol glycosides)
Group II: Diet beveragesExperimental Treatment1 Intervention
Soft drinks sweetened with artificial non-nutritive sweeteners (i.e. aspartame, acesulfame-K)
Group III: Regular beveragesActive Control1 Intervention
Sugar sweetened soft drinks

Find a Location

Who is running the clinical trial?

Laval UniversityLead Sponsor
434 Previous Clinical Trials
178,500 Total Patients Enrolled
26 Trials studying Metabolic Syndrome
1,974 Patients Enrolled for Metabolic Syndrome
Marie-Claude VohlPrincipal InvestigatorLaval University
3 Previous Clinical Trials
141 Total Patients Enrolled
2 Trials studying Metabolic Syndrome
118 Patients Enrolled for Metabolic Syndrome

Media Library

Aspartame-based soft drinks (Non-nutritive Sweetener) Clinical Trial Eligibility Overview. Trial Name: NCT03259685 — N/A
Metabolic Syndrome Research Study Groups: Regular beverages, Diet beverages, Stevia beverages
Metabolic Syndrome Clinical Trial 2023: Aspartame-based soft drinks Highlights & Side Effects. Trial Name: NCT03259685 — N/A
Aspartame-based soft drinks (Non-nutritive Sweetener) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03259685 — N/A
~5 spots leftby Dec 2025
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