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Cancer Vaccine

Blueberries + Exercise for Cognitive Impairment

N/A
Waitlist Available
Led By David C Nieman, DrPH
Research Sponsored by Appalachian State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Healthy, non-smoking male or female participants 65 to 85 years of age
Willingness to be a participant in this study only and not enter any other studies
Must not have
Diagnosis of Type I or Type 2 diabetes
History of signs or symptoms during rest or physical activity such as chest discomfort, unreasonable breathlessness, dizziness, fainting, or blackouts
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from pre-study to 6-weeks and 12-weeks

Summary

This trial will study how eating blueberries rich in flavonoids for 12 weeks, along with or without moderate exercise, can improve cognitive function in older adults experiencing age-related cognitive changes. The researchers

Who is the study for?
This trial is for healthy, non-smoking individuals aged 65-85 with mild cognitive decline. Participants must be physically inactive, willing to exercise (walking/stretching), avoid blueberries outside the study, and not use drugs affecting cognition. They can't have uncontrolled chronic conditions or a dementia diagnosis.
What is being tested?
The NIH study tests if eating flavonoid-rich blueberries combined with regular moderate exercise improves cognitive function in older adults experiencing age-related cognitive changes. It explores how diet and physical activity might influence gut health and cognition.
What are the potential side effects?
Potential side effects may include digestive discomfort from increased fiber intake due to blueberries and muscle soreness or fatigue from new physical activities like walking or stretching.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am a healthy, non-smoking individual aged between 65 and 85.
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I agree to only participate in this study and not join any others.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have been diagnosed with Type 1 or Type 2 diabetes.
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I have experienced symptoms like chest pain or fainting during rest or activity.
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I am not taking any medication for cognition or that affects my thinking.
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I have been diagnosed with dementia.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from pre-study to 6-weeks and 12-weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from pre-study to 6-weeks and 12-weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Cognition
Secondary study objectives
Gut microbiome
Maximal aerobic capacity
Urine blueberry metabolites

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: Blueberry + walkingExperimental Treatment2 Interventions
Blueberry intake combined with walking exercise.
Group II: Blueberry + stretchingExperimental Treatment2 Interventions
Blueberry intake combined with stretching exercise.
Group III: Placebo + stretchingActive Control2 Interventions
Placebo intake combined with stretching exercise.
Group IV: Placebo + walkingActive Control2 Interventions
Placebo intake combined with walking exercise.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Stretching
2019
N/A
~2330
Blueberry
2017
N/A
~210
Walking
2020
Completed Phase 2
~1560

Find a Location

Who is running the clinical trial?

Appalachian State UniversityLead Sponsor
44 Previous Clinical Trials
2,280 Total Patients Enrolled
David C Nieman, DrPHPrincipal InvestigatorAppalachian State Univ
15 Previous Clinical Trials
681 Total Patients Enrolled
~160 spots leftby Dec 2027
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